Page 94 - GTM-3-2

Global Translational Medicine RhPDGF-BB/gelatin sponge-treated FGG

the deposition of collagen and glycosaminoglycans and Ethics approval and consent to participate
promotes angiogenesis, which allows faster revascularization
of the wound. A signed written consent was obtained from each patient
before the procedure.
Compared to previous studies that prioritized the
separate use of individual materials, this study innovated Consent for publication
an alleviate means, combining rhPDGF-BB and gelatin No patient identifiers were used in this report.
sponge, to mitigate patient pain in the palatal graft
donor sites. A clear mechanism of action of rhPDGF-BB Availability of data
10
promoting more closed wound healing has been
established in the literature, thus lending tremendous Data are available from the corresponding author on
reasonable request.
corroboration to our clinical observations.
The results of the present study are consistent with References
the original hypothesis that we set out to examine that is 1. Kim DM, Neiva R. Periodontal soft tissue non-root coverage
the use of a more concentrated rhPDGF-BB solution in a procedures: A systematic review from the AAP Regeneration
gelatin sponge would improve patient comfort compared Workshop. J Periodontol. 2015;86(2 Suppl):S56-S72.
to PRF or gelatin sponges without rhPDGF-BB, which doi: 10.1902/jop.2015.130684
had never been shown to mitigate pain intensity
11
as much as the method demonstrated in the present 2. Griffin TJ, Cheung WS, Zavras AI, Damoulis PD.
report. Randomized controlled trials comparing PROMs Postoperative complications following gingival augmentation
procedures. J Periodontol. 2006;77(12):2070-2079.
for patients treated with rhPDGF-BB-soaked gelatin
sponges compared to gelatin sponges without rhPGF-BB doi: 10.1902/jop.2006.050296
are now warranted. Considering the limited sample size, 3. Ehab K, Abouldahab O, Hassan A, Fawzy El-Sayed KM.
lack of a control group, and treated sites, an additional Alvogyl and absorbable gelatin sponge as palatal wound
number of subjects in a randomized controlled trial for dressings following epithelialized free gingival graft
investigating further intervention is recommended for harvest: A randomized clinical trial. Clin Oral Investig.
further studies. 2020;24(4):1517-1525.
doi: 10.1007/s00784-020-03254-z
5. Conclusion
4. Tavelli L, Ravidà A, Saleh MHA, et al. Pain perception following
In summation, a swift placement of rhPDGF-BB-soaked epithelialized gingival graft harvesting: A randomized
gelatin sponges into palatal donor sites following FGG clinical trial. Clin Oral Investig. 2019;23(1):459-468.
harvesting can result in improved patient-reported doi: 10.1007/s00784-018-2455-5
outcomes, less patient discomfort, and an overall patient
post-operative experience. 5. Stavropoulou C, Atout RN, Brownlee M, Schroth RJ, Kelekis-
Cholakis A. A randomized clinical trial of cyanoacrylate
Acknowledgments tissue adhesives in donor site of connective tissue grafts.
J Periodontol. 2019;90(6):608-615.
None. doi: 10.1002/JPER.18-0475
Funding 6. Fujioka-Kobayashi M, Miron RJ, Moraschini V, Zhang Y,
Gruber R, Wang HL. Efficacy of platelet-rich fibrin on
None. bone formation, part 2: Guided bone regeneration, sinus
elevation and implant therapy. Int J Oral Implantol (Berl).
Conflict of interest 2021;14(3):285-302.
The authors declare no conflicts of interest. 7. Miron RJ, Moraschini V, Fujioka-Kobayashi M, et al. Use
of platelet-rich fibrin for the treatment of periodontal
Author contributions intrabony defects: A systematic review and meta-analysis.

Conceptualization: David Meister, Hom-Lay Wang Clin Oral Investig. 2021;25(5):2461-2478.
Investigation: Muhammad H. A. Saleh, Hussein Basma, doi: 10.1007/s00784-021-03825-8
Fatemeh Samavatijame 8. Bahammam MA. Effect of platelet-rich fibrin palatal
Writing – original draft: Muhammad H. A. Saleh, Fatemeh bandage on pain scores and wound healing after free
Samavatijame gingival graft: A randomized controlled clinical trial. Clin
Writing – review & editing: all authors Oral Investig. 2018;22(9):3179-3188.

Volume 3 Issue 2 (2024) 5 doi: 10.36922/gtm.2693