Page 20 - GTM-3-3

Global Translational Medicine Influence of estrogen on RV mitochondria in PH

doi: 10.1183/09031936.00010409 hypertension. J Mol Med (Berl). 2015;93(3):229-242.
25. Viales RR, Eichstaedt CA, Ehlken N, et al. Mutation in BMPR2 doi: 10.1007/s00109-015-1263-5
promoter: A ‘second hit’ for manifestation of pulmonary 35. Paulin R, Michelakis ED. The metabolic theory of pulmonary
arterial hypertension? PLoS One. 2015;10(7):e0133042.
arterial hypertension. Circ Res. 2014;115(1):148-164.
doi: 10.1371/journal.pone.0133042
doi: 10.1161/circresaha.115.301130
26. Machado RD, Eickelberg O, Elliott CG, et al. Genetics and 36. Velarde MC. Mitochondrial and sex steroid hormone
genomics of pulmonary arterial hypertension. J Am Coll crosstalk during aging. Longev Healthspan. 2014;3(1):2.
Cardiol. 2009;54(1 Suppl):S32-S42.
doi: 10.1186/2046-2395-3-2
doi: 10.1016/j.jacc.2009.04.015
37. Ohira H, deKemp R, Pena E, et al. Shifts in myocardial
27. Pfarr N, Szamalek-Hoegel J, Fischer C, et al. Hemodynamic fatty acid and glucose metabolism in pulmonary arterial
and clinical onset in patients with hereditary pulmonary hypertension: A potential mechanism for a maladaptive
arterial hypertension and BMPR2 mutations. Respir Res. right ventricular response. Eur Heart J Cardiovasc Imaging.
2011;12(1):99.
2016;17(12):1424-1431.
doi: 10.1186/1465-9921-12-99
doi: 10.1093/ehjci/jev136
28. Mair KM, Yang XD, Long L, et al. Sex affects bone 38. Lundgrin EL, Park MM, Sharp J, et al. Fasting 2-deoxy-2-
morphogenetic protein type II receptor signaling in [18F]fluoro-D-glucose positron emission tomography to
pulmonary artery smooth muscle cells. Am J Respir Crit detect metabolic changes in pulmonary arterial hypertension
Care Med. 2015;191(6):693-703.
hearts over 1 year. Ann Am Thorac Soc. 2013;10(1):1-9.
doi: 10.1164/rccm.201410-1802OC
doi: 10.1513/AnnalsATS.201206-029OC
29. Frump AL, Goss KN, Vayl A, et al. Estradiol improves right 39. Bokhari S, Raina A, Rosenweig EB, et al. PET imaging
ventricular function in rats with severe angioproliferative may provide a novel biomarker and understanding of
pulmonary hypertension: Effects of endogenous and right ventricular dysfunction in patients with idiopathic
exogenous sex hormones. Am J Physiol Lung Cell Mol pulmonary arterial hypertension. Circ Cardiovasc Imaging.
Physiol. 2015;308(9):L873-L890.
2011;4(6):641-647.
doi: 10.1152/ajplung.00006.2015
doi: 10.1161/circimaging.110.963207
30. Kawut SM, Archer-Chicko CL, DeMichele A, et al. 40. Kim Y, Goto H, Kobayashi K, et al. Detection of impaired
Anastrozole in pulmonary arterial hypertension. A fatty acid metabolism in right ventricular hypertrophy:
randomized, double-blind, placebo-controlled trial. Am J Assessment by I-123 beta-methyl iodophenyl pentadecanoic
Respir Crit Care Med. 2017;195(3):360-368.
acid (BMIPP) myocardial single-photon emission computed
doi: 10.1164/rccm.201605-1024OC tomography. Ann Nucl Med. 1997;11(3):207-212.
31. Ryan JJ, Archer SL. The right ventricle in pulmonary arterial doi: 10.1007/bf03164765
hypertension: Disorders of metabolism, angiogenesis and 41. Nagaya N, Got MY, Satoh T, et al. Impaired regional fatty
adrenergic signaling in right ventricular failure. Circ Res. acid uptake and systolic dysfunction in hypertrophied right
2014;115(1):176-188.
ventricle. J Nucl Med. 1998;39(10):1676-1680.
doi: 10.1161/circresaha.113.301129
42. Tian L, Neuber-Hess M, Mewburn J, et al. Ischemia-induced
32. Piao L, Fang YH, Cadete VJ, et al. The inhibition of pyruvate Drp1 and Fis1-mediated mitochondrial fission and right
dehydrogenase kinase improves impaired cardiac function ventricular dysfunction in pulmonary hypertension. J Mol
and electrical remodeling in two models of right ventricular Med (Berl). 2017;95(4):381-393.
hypertrophy: Resuscitating the hibernating right ventricle. doi: 10.1007/s00109-017-1522-8
J Mol Med (Berl). 2010;88(1):47-60.
43. Tian L, Wu D, Dasgupta A, et al. Epigenetic metabolic
doi: 10.1007/s00109-009-0524-6
reprogramming of right ventricular fibroblasts in pulmonary
33. Oikawa M, Kagaya Y, Otani H, et al. Increased [18 F] arterial hypertension: A pyruvate dehydrogenase kinase-
fluorodeoxyglucose accumulation in right ventricular free dependent shift in mitochondrial metabolism promotes
wall in patients with pulmonary hypertension and the effect right ventricular fibrosis. Circ Res. 2020;126(12):1723-1745.
of epoprostenol. J Am Coll Cardiol. 2005;45(11):1849-1855.
doi: 10.1161/circresaha.120.316443
doi: 10.1016/j.jacc.2005.02.065
44. Tian L, Potus F, Wu D, et al. Increased Drp1-mediated
34. Ryan J, Dasgupta A, Huston J, Chen KH, Archer SL. mitochondrial fission promotes proliferation and collagen
Mitochondrial dynamics in pulmonary arterial production by right ventricular fibroblasts in experimental

Volume 3 Issue 3 (2024) 10 doi: 10.36922/gtm.2494