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Global Translational Medicine Immunohistochemistry in pituitary adenomas

particularly in assessing plurihormonality. Our findings IARC; 2022. p. 10-15.
indicate a plurihormonal frequency of 28.9%, suggesting a 3. Saeger W, Lüdecke DK, Buchfelder M, Fahlbusch R,
significant overlap in hormone production among various Quabbe HJ, Petersenn S. Pathohistological classification of
adenoma types. pituitary tumors: Experience from the German pituitary
The integration of molecular profiling techniques may tumor registry. Eur J Endocrinol. 2017;176(2):193-201.
enhance the diagnostic precision of PA subtypes beyond 4. Sanchez-Tejada L, Moreno-Perez O, Alfayate R, et al.
the ability of traditional IHC. This advancement could lead Contribution of molecular analysis to the typification
to a reevaluation of the known prevalence of PAs, with of non-functioning pituitary adenomas. PLoS One.
important clinical implications for treatment strategies 2019;14(8):e0221268.
and patient management. The emerging understanding of 5. Dineen R, Stewart PM, Sherlock M, et al. The evolving
the molecular landscape of these tumors has the potential role of molecular profiling in the management of pituitary
to inform tailored therapeutic approaches, ultimately adenomas. Cancers (Basel). 2020;12(6):1628.
improving patient outcomes.
6. Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic
Acknowledgments architecture of type 2 diabetes. Nature. 2016;536(7614):41-47.
doi: 10.1038/nature18642
None.
7. DeStephano DB, Lloyd RV, Pike AM, Wilson BS. Pituitary
Funding adenomas. An immunohistochemical study of hormone
production and chromogranin localization. Am J Pathol.
None. 1984;116(3):464-472.
Conflict of interest 8. Molitch ME. Diagnosis and treatment of pituitary adenomas:
A review. JAMA. 2017;317(5):516-524.
The authors declare no conflicts of interest.
doi: 10.1001/jama.2016.19699
Author contributions 9. Zargar AH, Laway BA, Masoodi SR, et al. Clinical and

Conceptualization: Taieb Ach endocrine aspects of pituitary tumors. Saudi Med J.
Investigation: Nihed Abdessaied 2004;25(10):1428-1432.
Methodology: Koussay Ach 10. Trouillas J. In search of a prognostic classification of endocrine
Writing–original draft: Ach Taieb pituitary tumors. Endocr Pathol. 2014;25(2):124-132.
Writing–review & editing: All authors doi: 10.1007/s12022-014-9322-y
Ethics approval and consent to participate 11. Balinisteanu, B, Ceauşu RA, Cîmpean AM, et al.
Conventional examination versus immunohistochemistry
The Institutional Review Board Statement obtained from in the prediction of hormone profile of pituitary adenomas.
University Hospital of Sousse Tunisia. Approval number: An analysis on 142 cases. Rom J Morphol Embryol.
15/2023. Informed consent was obtained from all subjects 2011;52(3 Suppl):1041-1045.
involved in the study.
12. Sen A, Das C, Mukhopadhyay M, Mukhopadhyay S, Deb S,
Consent for publication Mukhopadhyay B. Cytohistological correlation in pituitary
tumor and immunological assessment with the help of
Patients consented on the publication of their data. Ki-67. J Postgrad Med. 2017;63(2):96-99.
Availability of data doi: 10.4103/0022-3859.192797
13. Brito J, Cortés ME, Rodríguez F. Immunohistochemistry for
Data will be made available on reasonable request to the pituitary hormones and Ki-67 in growth hormone producing
corresponding author. pituitary adenomas. Rev Med Chil. 2008;136(7):831-836.

References 14. Liu DG. Immunohistochemical and ultrastructural study
of plurihormonal pituitary adenomas. Zhonghua Yi Xue Za
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