Page 36 - GTM-4-2

Global Translational Medicine Small RNA therapy for pancreatic cancer

pancreatic cancer through targeting STAT3. PLoS One. in action: Biogenesis, function and regulation. Nat Rev
2013;8(9):e73803. 10.1038/s41576-023-00611-y Genet. 2023;24(12):816-833.
doi: 10.1371/journal.pone.0073803 doi: 10.1038/s41576-023-00611-y
49. Zou Y, Li J, Chen Z, et al. miR-29c suppresses pancreatic 61. Alshaer W, Zureigat H, Al Karaki A, et al. siRNA: Mechanism
cancer liver metastasis in an orthotopic implantation model of action, challenges, and therapeutic approaches. Eur J
in nude mice and affects survival in pancreatic cancer Pharmacol. 2021;905:174178.
patients. Carcinogenesis. 2015;36(6):676-684.
doi: 10.1016/j.ejphar.2021.174178
doi: 10.1093/carcin/bgv027
62. Dhuri K, Bechtold C, Quijano E, et al. Antisense
50. Xu J, Wang T, Cao Z, et al. MiR-497 downregulation oligonucleotides: An emerging area in drug discovery and
contributes to the malignancy of pancreatic cancer development. J Clin Med. 2020;9(6):2004.
and associates with a poor prognosis. Oncotarget.
2014;5(16):6983-6993. doi: 10.3390/jcm9062004
63. Wu H, Lima WF, Zhang H, Fan A, Sun H, Crooke ST.
doi: 10.18632/oncotarget.2184
Determination of the role of the human RNase H1 in the
51. Li L, He Z, Zhu C, et al. MiR-137 promotes anoikis through pharmacology of DNA-like antisense drugs. J Biol Chem.
modulating the AKT signaling pathways in pancreatic 2004;279(17):17181-17189.
cancer. J Cancer. 2020;11(21):6277-6285.
doi: 10.1074/jbc.M311683200
doi: 10.7150/jca.44037
64. Yin W, Rogge M. Targeting RNA: A transformative
52. Zuo H. MicroRNA Expression in Pancreatic Cancer. China: therapeutic strategy. Clin Transl Sci. 2019;12(2):98-112.
Sun Yat-sen University; 2008.
doi: 10.1111/cts.12624
53. Li R, Hu Y, Hou S. An exploration of oral-gut pathogens
mediating immune escape of pancreatic cancer via miR-21/ 65. Bennett CF, Swayze EE. RNA targeting therapeutics:
PTEN axis. Front Microbiol. 2022;13:928846. Molecular mechanisms of antisense oligonucleotides
as a therapeutic platform. Ann Rev Pharmacol Toxicol.
doi: 10.3389/fmicb.2022.928846 2010;50:259-293.
54. Wang J, Guo J, Fan H. MiR-155 regulates the proliferation doi: 10.1146/annurev.pharmtox.010909.105654
and apoptosis of pancreatic cancer cells through targeting
SOCS3. Eur Rev Med Pharmacol Sci. 2019;23(12): 66. Passini MA, Bu J, Richards AM, et al. Antisense
5168-5175. oligonucleotides delivered to the mouse CNS ameliorate
symptoms of severe spinal muscular atrophy. Sci Transl Med.
doi: 10.26355/eurrev_201906_18181 2011;3(72):72ra18.
55. Xu Q, Li P, Chen X, et al. miR-221/222 induces pancreatic doi: 10.1126/scitranslmed.3001777
cancer progression through the regulation of matrix
metalloproteinases. Oncotarget. 2015;6(16):14153-14164. 67. Chai C, Xie Z, Grotewold E. SELEX (systematic evolution
of ligands by exponential enrichment), as a powerful tool
doi: 10.18632/oncotarget.3686 for deciphering the protein-DNA interaction space. Methods
56. Sun XJ, Liu BY, Yan S, et al. MicroRNA-29a promotes Mol Biol. 2011;754:249-258.
pancreatic cancer growth by inhibiting tristetraprolin. Cell doi: 10.1007/978-1-61779-154-3_14
Physiol Biochem. 2015;37(2):707-718.
68. Zhang Y, Lai BS, Juhas M. Recent advances in aptamer
doi: 10.1159/000430389 discovery and applications. Molecules. 2019;24(5):941.
57. Lian M, Mortoglou M, Uysal-Onganer P. Impact of hypoxia- doi: 10.3390/molecules24050941
induced miR-210 on pancreatic cancer. Curr Issues Mol Biol.
2023;45(12):9778-9792. 69. Khan S, Hussain A, Fahimi H, et al. A review on the
therapeutic applications of aptamers and aptamer-
doi: 10.3390/cimb45120611 conjugated nanoparticles in cancer, inflammatory and viral
58. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often diseases. Arab J Chem. 2022;15(2):103626.
flanked by adenosines, indicates that thousands of human doi: 10.1016/j.arabjc.2021.103626
genes are microRNA targets. Cell. 2005;120(1):15-20.
70. Kim YK. RNA therapy: Rich history, various applications
doi: 10.1016/j.cell.2004.12.035 and unlimited future prospects. Exp Mol Med. 2022;54(4):
59. Bartel DP. Metazoan MicroRNAs. Cell. 2018;173(1):20-51. 455-465.
doi: 10.1016/j.cell.2018.03.006 doi: 10.1038/s12276-022-00757-5
60. Shang R, Lee S, Senavirathne G, Lai EC. microRNAs 71. Gragoudas ES, Adamis AP, Cunningham ET Jr., Feinsod M,

Volume 4 Issue 2 (2025) 28 doi: 10.36922/gtm.8247