Page 434 - IJB-10-2

International Journal of Bioprinting In vitro 3D pancreatic acinar unit

need for supports, mandrels, or sacrificial materials. The Ethics approval and consent to participate
constructed PCL scaffold represents, at the microscale, a Not applicable.
biomimetic porous network able to support the growth
and proliferation of stromal cells over several weeks. In Consent for publication
particular, human fibroblasts and HPDE overexpressing
the KRAS oncogene were used to replicate the stromal Not applicable.
and cancer epithelial components, respectively. The ability
of this model in promoting the formation of a stromal Availability of data
tissue after 28 days of culture, as well as the capability in Data are available from the corresponding author upon
replicating the compartmentalized architecture typical of reasonable request.
the pancreatic cancer microenvironment by hosting both
stromal cells and epithelial cells, was assessed. Indeed, References
the specific localization of the epithelial cells within the
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Funding doi: 10.1186/s12943-018-0815-z

This project was carried out with the support of Fondazione 5. Pothula SP, Pirola RC, Wilson JS, Apte MV. Pancreatic stellate
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Conflict of interest stellate cell: Pandora’s box for pancreatic disease biology.
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The authors declare no conflicts of interest. doi: 10.3748/wjg.v23.i3.382

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Conceptualization: Gianluca Ciardelli, Chiara Tonda-Turo Gastroenterology. 2013;144:1210-1219.
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Funding acquisition: Gianluca Ciardelli, Chiara Tonda-Turo The role of stellate cells in pancreatic ductal adenocarcinoma:
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Chiara Tonda-Turo doi: 10.3389/fonc.2020.621937
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Writing – original draft: Viola Sgarminato, cells and cancer cells in pancreatic cancer: new insights into
Chiara Tonda-Turo stromal biology. Cancer Lett. 2017;392:83-93.
Writing – review & editing: Gianluca Ciardelli doi: 10.1016/j.canlet.2017.01.041
Volume 10 Issue 2 (2024) 426 doi: 10.36922/ijb.1975