Page 9 - IJB-10-2

International

Journal of Bioprinting

REVIEW ARTICLE
2D/3D-printed PEDOT/PSS conductive hydrogel

for biomedical sensors

Bin Huang , Zengjie Zhao , Yayu Zheng , Kaidi Xu , Dan Wang ,
1
1
1
1
1
Qingyuan Yang , Tingting Yang , Xiaojie Yang *, and Huangqin Chen *
1
2
1
1
1 School of Stomatology and Ophthalmology, Hubei University of Science and Technology, Xianning
City, Hubei Province, China
2 School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and
Technology, Xianning City, Hubei Province, China
(This article belongs to the Special Issue: Advances in 3D Printing of Hydrogels)
Abstract
The integration of conductive hydrogels and advanced three-dimensional (3D)
printing is a trigger of the development of biomedical sensors for healthcare
diagnostics and personalized treatment. Poly(3,4-ethylenedioxythiophene):poly(styr
ene sulfonate) (PEDOT:PSS) is a versatile conductive hydrogel materials renowned for
its exceptional conductivity and hydrophilicity, and 3D printing technology allows
for precise and customized fabrication of electronic components and devices. In
this review, we aim to explore the potential of 3D-printed PEDOT/PSS conductive
hydrogel in the fabrication of biomedical sensors, with a focus on their distinct
characteristics, application potential, and systematic classification. We also discuss
the methods for fabricating PEDOT:PSS hydrogel electronic devices by employing
3D printing techniques, including extrusion-based 3D printing technology (fused
*Corresponding authors: deposition modeling, direct ink writing, and inkjet printing), powder-based 3D
Xiaojie Yang
(mailyangxiaojie@126.com) printing technology (selective laser sintering and selective laser melting), and
Huangqin Chen photopolymerization-based 3D printing technology (stereolithography and
(chenhuangqin79@163.com) digital light processing). The applications of 2D/3D-printed PEDOT:PSS hydrogels
in biomedical sensors, such as strain sensors, pressure sensors, stretchable
Citation: Huang B, Zhao Z,
Zheng Y, et al. 2D/3D-printed sensors, electrochemical sensors, temperature sensors, humidity sensors, and
PEDOT/PSS conductive hydrogel electrocardiogram sensor, are also summarized in this review. Finally, we provide
for biomedical sensors. Int J insights into the development of 3D-printed PEDOT:PSS-based biomedical sensors
Bioprint. 2024;10(2):1725.
doi: 10.36922/ijb.1725 and the innovative techniques for biomedical sensor integration.
Received: August 31, 2023
Accepted: October 26, 2023 Keywords: PEDOT:PSS; 3D printing; Conductive hydrogel; Biomedical sensor
Published Online: January 16, 2024
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution 1. Introduction
License, permitting distribution,
and reproduction in any medium, Hydrogels are intricate three-dimensional (3D) polymer networks that form through
provided the original work is chemical and/or physical crosslinking in an aqueous solution. They harbor vast potential
properly cited. in various domains, spanning from tissue engineering scaffolds to drug delivery carriers
Publisher’s Note: AccScience and biomedical devices. Hydrogels bear high resemblance to extracellular matrix
Publishing remains neutral with for their exceptional capacity to absorb and retain water. They offer a stable micro-
regard to jurisdictional claims in
published maps and institutional environment that allows cellular activities and facilitates tissue formation, all the while
affiliations. maintaining outstanding biocompatibility. Furthermore, these versatile materials display

Volume 10 Issue 2 (2024) 1 doi: 10.36922/ijb.1725