Page 205 - IJB-10-3

International

Journal of Bioprinting

RESEARCH ARTICLE
Polydopamine chelating strontium on graphene

oxide enhances the mechanical and osteogenic
induction properties of PLLA/PGA bone scaffold

Feng Yang , Yun Lin , Saipu Shen , Yulong Gu , Cijun Shuai 1,2,3 *, and Pei Feng *
1
1†
1†
1
1
1 State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of
Mechanical and Electrical Engineering, Central South University, Changsha, Hunan, China
2 Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang,
Jiangxi, China
3
College of Mechanical Engineering, Xinjiang University, Urumqi, Xinjiang, China

Abstract

Poly (lactic acid)/poly (glycolic acid) (LG) bone scaffold exhibits good biocompatibility
for bone defect regeneration but lacks satisfactory mechanical and osteogenic
induction properties. Here, graphene oxide (GO) was encapsulated by polydopamine
(PDA) via self-polymerization of dopamine, and strontium (Sr) was loaded onto GO
by the chelation of PDA. The modified GO was added to the LG scaffold prepared via
† These authors contributed equally
to this work. selective laser sintering as a reinforcing phase to improve the mechanical properties
and osteogenic induction properties. The results indicated that the tensile and
*Corresponding authors:
Cijun Shuai compressive strengths of the scaffold with 1.5 wt% modified GO were 9.49 MPa and
(shuai@csu.edu.cn) 19.22 MPa, respectively, representing 67.08% and 95.33% improvement compared
Pei Feng to the LG scaffold. The enhancement mechanisms of the modified GO in the scaffold
(fengpei@csu.edu.cn) included crack branching, crack deflection, crack pinning, crack bridging, and pulling
Citation: Yang F, Lin Y, Shen S, out. More importantly, the scaffold with modified GO exhibited superior bioactivity
Gu Y, Shuai C, Feng P. and osteogenic induction properties compared to the LG scaffold, because PDA
Polydopamine chelating strontium could chelate calcium ions derived from the surrounding physiological environment,
on graphene oxide enhances
the mechanical and osteogenic and the calcium ions attracted phosphate ions through electrostatic interactions to
induction properties of PLLA/PGA promote the apatite layer deposition. Additionally, the presence of Sr in the scaffold
bone scaffold. promoted the proliferation and differentiation of osteoblasts, thereby improving
Int J Bioprint. 2024;10(3):1829.
doi: 10.36922/ijb.1829 osteogenic induction properties.
Received: September 13, 2023
Accepted: November 17, 2023 Keywords: Graphene oxide; Polydopamine, Strontium; Mechanical properties;
Published Online: January 12, 2024
Osteogenic induction properties
Copyright: © 2024 Author(s).
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution, 1. Introduction
and reproduction in any medium,
provided the original work is Graphene oxide (GO) as a reinforcing material of biopolymer bone scaffold has
properly cited. attracted extensive attention because of its excellent mechanical properties as well as
1-5
Publisher’s Note: AccScience good biocompatibility for cell adhesion and proliferation. Poly (lactic acid) (PLLA)/
Publishing remains neutral with poly (glycolic acid) (PGA) (named LG) composite bone scaffold obtained by blending
regard to jurisdictional claims in
published maps and institutional PLLA with PGA is endowed with good biocompatibility and a suitable degradation
affiliations. rate. 6-10 Besides, the mechanical properties of the LG scaffold can be enhanced by

Volume 10 Issue 3 (2024) 197 doi: 10.36922/ijb.1829