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International Journal of Bioprinting Pregabalin impact on 3D neuronal models

Conflict of interest Further disclosure
The authors declare no conflicts of interest. Part of the findings have been presented at the conference
Neuroscience 2023 held in Washington, USA.
Author contributions
Conceptualization: Raed I. Felimban, Heba A. Alkhatabi, References
Abdulaziz Alsharif, Hamza Habeeballah 1. Alles SR, Cain SM, Snutch TP. Pregabalin as a pain
Data curation: Walaa F. Alsanie, Majid Alhomrani, therapeutic: beyond calcium channels. Front Cell Neurosci.
Abdulhakeem S. Alamri, Sherin Abdelrahman, 2020;14:83.
Charlotte A. E. Hauser, Ahmed Gaber doi: 10.3389/fncel.2020.00083
Formal analysis: Walaa F. Alsanie, Majid Alhomrani, 2. Cross AL, Viswanath O, Sherman Al, Pregabalin I.
Abdulhakeem S. Alamri, Sherin Abdelrahman, StatPearls. Treasure Island, FL, USA: StatPearls Publishing;
Charlotte A. E. Hauser, Ahmed Gaber 2023. Available online: (accessed on 1 June, 2023).
Funding acquisition: Majid Alhomrani, Walaa F. Alsanie, https://www.ncbi.nlm.nih.gov/books/NBK470341/
Charlotte A. E. Hauser, Sherin Abdelrahman 3. Bidari A, Moazen-Zadeh E, Ghavidel-Parsa B, Rahmani
Investigation: Yusuf S. Althobaiti, Charlotte A. E. Hauser, S, Hosseini S, Hassankhani A. Comparing duloxetine and
Bassem M. Raafat pregabalin for treatment of pain and depression in women
Methodology: Sherin Abdelrahman, Alexander U. Valle- with fibromyalgia: an open-label randomized clinical trial.
Pérez, Majid Alhomrani, Walaa F. Alsanie, Ebtisam DARU. 2019;27(1):149-158.
Abdulah Alosimi, Ahmed Gaber doi: 10.1007/s40199-019-00257-4
Project administration: Bassem M. Raafat 4. Moulin D, Boulanger A, Clark A, et al. Pharmacological
Software: Walaa F. Alsanie, Abdulhakeem S. Alamri, management of chronic neuropathic pain: revised consensus
Ahmed Gaber statement from the Canadian Pain Society. Pain Res Manag.
Supervision: Walaa F. Alsanie, Charlotte A. E. Hauser, 2014;19(6):328-335.
Majid Alhomrani, Ahmed Gaber doi: 10.1155/2014/754693
Validation: Yusuf S. Althobaiti, Majid Alhomrani, Walaa 5. Dworkin RH, Corbin AE, Young JP, et al. Pregabalin for the
F. Alsanie treatment of postherpetic neuralgia: a randomized, placebo-
Visualization: Raed I. Felimban, Heba A. Alkhatabi, controlled trial. Neurology. 2003;60(8):1274-1283.
Abdulaziz Alsharif, Hamza Habeeballah doi: 10.1212/01.wnl.0000055433.55136.55
Writing — original draft preparation: Walaa F. Alsanie, 6. Lesser H, Sharma U, LaMoreaux L, Poole RM. Pregabalin
Sherin Abdelrahman relieves symptoms of painful diabetic neuropathy: a
Writing — review and editing: Walaa F. Alsanie, Sherin randomized controlled trial. Neurology. 2004;63(11):
Abdelrahman, Alexander U. Valle-Pérez, Charlotte A. 2104-2110.
E. Hauser, Ahmed Gaber, Abdulaziz Alsharif doi: 10.1212/01.wnl.0000145767.36287.a1
7. Elgazzar FM, Elseady WS, Hafez AS. Neurotoxic effects of
Ethics approval and consent to participate pregabalin dependence on the brain frontal cortex in adult
The animal experiments were carried out in compliance male albino rats. Neurotoxicology. 2021;83:146-155.
with international standards for the use of animals in doi: 10.1016/j.neuro.2021.01.004
research. This study received clearance from King Abdulaziz 8. Morse DC. Embryo‐fetal developmental toxicity studies
University and was approved by the Taif University Ethics with pregabalin in mice and rabbits. Birth Defects Res B Dev
Committees (7-CEGMR-Bioeth). Reprod Toxicol. 2016;107(2):85-93.
doi: 10.1002/bdrb.21174
Consent for publication 9. Kułak-Bejda A, Waszkiewicz N, Popławska R, Bejda G.
The impact of high doses of pregabalin on pregnancy–case
Not applicable
report. Psychiatry Clin Psychopharmacol. 2019;29(1):97-99.
doi: 10.1080/24750573.2018.1505452
Availability of data
10. Cross AL, Viswanath O, Sherman AL. Pregabalin. StatPearls
All data that support the findings of this study are included [Internet]; 2021. Available online: (accessed April 17, 2023).
in the article and supplementary file. https://www.ncbi.nlm.nih.gov/books/NBK470341/

Volume 10 Issue 4 (2024) 422 doi: 10.36922/ijb.3010