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3D printed fabric silicone composite
                        A                                                        C







                                                                                 D

                         B




                                                                                 E






           Figure 2. Schematic of workflow and production process of additively manufactured silicone inserts:
           Three-dimensional (3D) scanned geometry of (A) hypertrophic scars (HS) with refined insertion models
           and (B) hand with refined web insertion models. Photo of 3D printed: (C) Insertion for the HS; (D) and
           (E) web insertion for webspace between second and third digits; Scale bar: 10 mm.

           materials. After that, the 3D models were refined,   of pressure at the interface between the scar and
           and the model orientation was adjusted for printing.   garment for effective scar reduction by combining
           Finally, the 3D models were imported into the 3D-   and reinforcing the pressure, hydration, and static
           printer (3D-Bioplotter  Manufacturer Series) for    electricity stimulation together .
                                                                                           [17]
                                ®
           the additive manufacturing process. Figure 2C-E is
           the photo of the silicone inserts which can function   3.2 Mechanical  performance of fabricated
           as orthoses to prevent web space contractures       composites
           during therapy  [17,33] .  When comparing the       3.2.1 Adhesion force
           traditional manual insert material production and
           the 3D printing process, the 3D printing production   To achieve an additive manufactured product with
           process minimizes human errors in orthosis design   high resolution, a print silicone mixture with high
           and achieves a reliable and repeatable geometry of   viscosity needs to be used. However, high viscosity
           inserts. Once the silicone insert was 3D printed on   silicone  mixtures  do  not  easily  diffuse  through
           fabric, it could be sewn as a part of the pressure   fabric; hence, resulted in poor shear strength of
           garment to increase pressure onto the specific body   the 3D printed silicone and fabric. To prevent the
           region and prevent the distal migration of scars.   pressure garment fabric and 3D printed silicone
           For silicone gel sheet therapy, the planar shape of   inserts from separating during wearing, a multi-
           silicone gel sheet is usually larger than the size of   material printing approach was adopted to improve
           HS regardless of the 3D body shapes and curvatures,   the force of the adhesion.  The schematic of this
           thus  leading  to  displacements,  ill-fitting,  and   approach is shown in Figure 4. During the printing
           discomfort during the treatment, Figure 3A and B.   process, a lower viscosity (around 7400 Mpa·s)
           When comparing with silicone gel sheet therapy,     silicone mixture was used in the first printed layer,
           the accurate geometric shape of the printed silicone   while a higher viscosity (around 1,080,000 Mpa·s)
           inserts prevents negative impacts such as excessive   silicone mixture was used in the other printed
           sweating, pruritus, and contact dermatitis of the   layers.  The viscosity curve of the silicone print
           healthy skin next to the HS, Figure 3C. Moreover,   mixtures with different thickener contents at 0°C,
           the silicone inserts can administer the right amount   which is the temperature of the print head, as a

           74                          International Journal of Bioprinting (2020)–Volume 6, Issue 2
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