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REVIEW ARTICLE

Fibrin-based Bioinks: New Tricks from an Old Dog

Anastasia Shpichka *, Daria Osipova , Yuri Efremov , Polina Bikmulina ,
1
1,2
1
1
Nastasia Kosheleva , Marina Lipina , Evgeny A. Bezrukov , Roman
5
6
3,4
B. Sukhanov , Anna B. Solovieva , Massoud Vosough , Peter Timashev 1,2,7,9
8
6
7
1 Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University,
Moscow, Russia
2 Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia
3 Department of Molecular and Cell Pathophysiology, FSBSI Institute of General Pathology and Pathophysiology, Moscow,
Russia
4 Department of Embryology, Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia
5 Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov First Moscow State Medical University, Moscow,
Russia
6 Department of Urology, Sechenov First Moscow State Medical University, Moscow, Russia
7 Department of Polymers and Composites, NN Semenov Institute of Chemical Physics, Moscow, Russia
8 Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology,
ACECR, Tehran, Iran
9 Institute of Photon Technologies, Federal Research Center Crystallography and Photonics RAS, Moscow, Russia

Abstract: For the past 10 years, the main efforts of most bioprinting research teams have focused on creating new bioink
formulations, rather than inventing new printing set-up concepts. New tissue-specific bioinks with good printability, shape fidelity,
and biocompatibility are based on “old” (well-known) biomaterials, particularly fibrin. While the interest in fibrin-based bioinks is
constantly growing, it is essential to provide a framework of material’s properties and trends. This review aims to describe the fibrin
properties and application in three-dimensional bioprinting and provide a view on further development of fibrin-based bioinks.
Keywords: Fibrin, Bioink, Tissue engineering, Regenerative medicine, Bioprinting, Biofabrication

*Corresponding Author: Anastasia Shpichka, Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov First
Moscow State Medical University, Moscow, Russia; ana-shpichka@yandex.ru
Received: February 28, 2020; Accepted: March 15, 2020; Published Online: April 29, 2020
(This article belongs to the Special Section: Bioprinting in Russia)

Citation: Shpichka A, Osipova D, Efremov Y, et al., 2020, Fibrin-based Bioinks: New Tricks from an Old Dog. Int J Bioprint,
6(3): 269. Doi: 10.18063/ijb.v6i3.269.

1 Introduction To date, the technical step has almost passed,
and the main approaches in printing set-ups
Tissue engineering, particularly three-dimensional have been already presented and are based on
(3D) bioprinting, is one of the most rapidly developing extrusion, droplet deposition, stereolithography,
fields in biomedicine. As any cutting-edge technology, and laser-induced forward transfer [1-4] . However,
3D bioprinting requires both complex equipment the material step involving bioinks is in progress.
and novel materials. Hence, its development can be Bioinks consisting of cells (or spheroids)
divided into at least two steps: Technical and material. and biomaterials are an essential element of 3D

© 2020 Shpichka, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International
License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the
original work is properly cited.
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