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bioprinted tissue has raised €5 million in their manufacturing approaches as means to confer
Series A round in 2018. Poietis has established complex specific geometric shapes, organoleptic
partnerships with companies such as Badische qualities, or nutritional characteristics to the final
Anilin und Soda Fabrik and. The contributors product.
to this round included Nouvelle Aquitaine Co- While none of the cell-based meat startups
investment Fund. This has provided the company have not rolled out their products on any market
with financial resources that will enable them to yet, plant-based alternatives have been growing
accelerate compatibility with regulations and by leaps and bounds over the recent years,
good manufacturing practices requirements. The culminating in the successful IPO of Beyond
company has announced that it could produce Meat, an American company, that produces a
the first bioprinted tissues for implantation into range of meat alternatives using a mix of various
patients in 2021 . plant proteins, and achieved more than 200%
[75]
[78]
[79]
In 2019, Aspect Biosystems, a Canadian biotech growth . Spain-based Novameat and Israeli
[80]
company, have raised US$ 20 million during their Redefine Meat now use 3D printing to create
Series A from Radical Ventures, a VC firm focused more sophisticated plant-based products; while
on companies that aim to solve global problems the former focuses on exact material formulation
as well us Pangaea Ventures, Pallasite Ventures, and simulation of proper meat texture, the latter
and Rhino Ventures. The company specializes in develops multi-layered plant-based steak structure.
microfluidic 3D bioprinting. Aspect Biosystems Cell-based meat (also known as in vitro meat
have created a bioprinting platform for production or IVM) is another approach to production of
of human tissues . alternative protein. Despite not being present on
[76]
Allevi, formerly known as Biobots, creates the market, cultured meat products still attract
desktop 3D bioprinters. The company’s clients attention from potential consumers (Figure 4),
include companies such as AbbVie, GSK, and some studies show that as many as 66% of US
[81]
Johnson & Johnson. The company was founded adults would try meat grown from animal cells .
in 2014 and has US$ 3.6 million in funding raised Cultured meat startups vary widely in their
up to date . approach to product development (Table 2). Since
[77]
We may expect the industry to start one of the major barriers, serum-free medium
consolidating in the next few years through formulation, was overcome in November 2019
mergers of bioprinting companies with each other by Mosa Meats that was the first to introduce a
[82]
and with strategic partners through acquisitions, cell-based burger patty , several companies
reflecting the general trend of the increased interest now focus on using bioprinting to create unique
of industry leaders in regenerative medicine and products.
drug discovery through testing on 3D models. Since the cost of final product is still expected
to be prohibitive during early stages, there are
6 Food industry various possible applications, for example,
production of cultured meat in space . Space
[83]
Another emerging industry where bioprinting is launches incur high costs and constant resupply
widely used is alternative protein food technology. is not a viable solution for long-term manned
There are two major fields of alternative protein: missions. Therefore, creation of sustainable food
Plant-based meat products and cultured meat production systems is a high priority for multiple
products. Plant-based products use specific plant space agencies.
proteins and other supplements to imitate taste and Keeping crewmembers fed during such
texture of meat, while cell-based products aim to expeditions will face several challenges, and
grow various cell types, which constitute natural cultured meat products can potentially solve
meat tissues in vitro and then assemble these most of them. Using water recovery system in
cells into a final product. Both fields use additive combination with serum-free medium produced
International Journal of Bioprinting (2020)–Volume 6, Issue 3 71
