Page 532 - IJB-9-6

International

Journal of Bioprinting

REVIEW ARTICLE
Strontium-doped calcium silicate scaffolds

with enhanced mechanical properties and
tunable biodegradability fabricated by vat

photopolymerization

Yinjin Li , Jin Su , Annan Chen *, Yifei Li , Xi Yuan , Kezhuo Chen ,
1,2
1,2
4
3
1,2
1,2
Zhaoqing Li , Chunze Yan , Jian Lu , and Yusheng Shi 1,2
5
1,2
6,7
1 State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials
Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
2 Engineering Research Center of Ceramic Materials for Additive Manufacturing, Ministry of
Education, Wuhan 430074, China
3
Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan 430030, China
4 Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life
Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
5 Wuhan Zeqing Technology Co. Ltd., Wuhan 430074, China
6 Centre for Advanced Structural Materials, Department of Mechanical Engineering, City University
of Hong Kong, Hong Kong
7 Centre for Advanced Structural Materials, Department of Mechanical Engineering, City University
of Hong Kong, Shenzhen Research Institute, Greater Bay Joint Division, Shenyang National
Laboratory for Materials Science, Shenzhen 518057, China
(This article belongs to the Special Issue: Bioprinting Tissues for Disease Modeling, Drug Development and
Drug Testing)
*Corresponding author:
Annan Chen
(AnnanChenNUAA@hust.edu.cn) Abstract
Citation: Li Y, Su J, Chen A, et al.,
2023, Strontium-doped calcium Strontium-doped calcium silicate (SrCS) bioceramics have demonstrated outstanding
silicate scaffolds with enhanced vasculogenic ability to repair large segmental bone defects, while their poor mechanical
mechanical properties and tunable properties and rapid degradation rate remain the major obstacles in clinical treatment.
biodegradability fabricated by vat
photopolymerization. Int J Bioprint, Here, we proposed a novel approach to significantly enhance the mechanical properties
9(6): 1233. of SrCS bioceramics with tunable biodegradability using micron barium titanate-based
https://doi.org/10.36922/ijb.1233 (BTA) powders as a dopant. Biomimetic SrCS-BTA scaffolds with triply periodic minimal
Received: April 27, 2023 surface structures were fabricated by vat photopolymerization. The effects of BTA
Accepted: July 21, 2023 content on microtopography, mechanical properties, degradability, and bioactivity
Published Online: September 14,
2023 of composite scaffolds were studied. On the one hand, the BTA greatly increased the
maximum densification rate of SrCS ceramics by 84.37%, while the corresponding
Copyright: © 2023 Author(s). densification temperature decreased by 95°C. On the other hand, CaTiO generated
This is an Open Access article 3
distributed under the terms of the by the reaction of SrCS and BTA intercepted cracks at the grain boundaries, and thus,
Creative Commons Attribution the mechanical properties were enhanced due to the pinning effect. The SrCS-40BTA
License, permitting distribution, scaffold exhibited much higher compressive strength and elastic modulus by 296%
and reproduction in any medium,
provided the original work is compared with the pure SrCS scaffold. The energy absorption of SrCS-40BTA scaffolds
properly cited. was 5.6 times higher than that of the pure SrCS scaffold. In addition, biocompatible
Publisher’s Note: AccScience SrCS-BTA scaffolds with lower degradation rates can play a supporting role in the
Publishing remains neutral with process of repair for a longer duration. This work provides a promising strategy to
regard to jurisdictional claims in fabricate biomimetic scaffolds with highly enhanced mechanical properties and
published maps and institutional
affiliations. tunable biodegradability for repairing damaged large segmental bone tissues.

Volume 9 Issue 6 (2023) 524 https://doi.org/10.36922/ijb.1233