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International Journal of Bioprinting Sr-doped printed scaffolds for bone repair

of bone tissue. VEGF expression is strongly associated Author contributions
87
with neovascularization, and our immunofluorescence Conceptualization: Qiping Huang, Xiang Li, Weikang Xu,
88
staining results demonstrated that the PSBP scaffolds Qingde Wa
effectively promoted VEGF expression. This enhancement Data curation: Qiping Huang, Xiang Li, Qinghong Fan,
is attributed to the synergistic pro-angiogenic effects of Qian Du, Guangquan Zhao, Yuanhao Lv, Yixiao Wang,
Sr² and Si⁴ released by SrBG. Furthermore, surface Weikang Xu, Qingde Wa
+
89
+
modification with PDA further enhanced angiogenesis Formal analysis: Qiping Huang, Xiang Li, Qian Du,
and maturation of the cell as well as tissue. 90,91
Guangquan Zhao, Yuanhao Lv, Yixiao Wang
Overall, the PDA/SrBG/PCL composite scaffolds Funding acquisition: Weikang Xu, Qingde Wa
prepared in this study can better regulate the immune Investigation: Qiping Huang, Xiang Li
microenvironment, promote blood vessel regeneration, and Methodology: Qiping Huang, Xiang Li
facilitate bone defect repair. Nonetheless, the study had several Project administration: Qiping Huang, Xiang Li, Qian Du,
limitations, namely the short observation period and the Guangquan Zhao, Yuanhao Lv, Yixiao Wang
preliminary in vivo investigation, thereby warranting further Resources: Qiping Huang, Xiang Li
investigation into the mechanism of bone defect repair. Validation: Weikang Xu, Qingde Wa
Visualization: Weikang Xu, Qingde Wa
5. Conclusion Writing – original draft: Qiping Huang, Xiang Li
Writing – review and editing: Weikang Xu, Qingde Wa
In this study, a PDA/SrBG/PCL composite scaffold was
fabricated, combining the multifunctional properties of Ethics approval and consent to participate
material modification, immunomodulation, and osteogenesis
induction. Overall, the PDA/SrBG/PCL scaffolds facilitated All animal experiments were performed according to the
bone differentiation in vitro and bone repair in an in vivo protocol approved by the Institutional Animal Care and
cranial defect model. Therefore, the composite scaffold may Use Committee of Guangdong Quality Supervision and
potentially overcome the clinical limitations of traditional PCL Testing Station for Medical and Health Care Appliances
scaffolds and mark a shift from mere structural replacement to (Approval ID: ZMU21-2412-019).
functional reconstruction in bone tissue engineering, offering
a valuable reference for the future development of advanced Consent for publication
bone repair materials. Not applicable.

Acknowledgments Availability of data
None. Upon reasonable request, data can be obtained from the
corresponding author.
Funding
This research was supported by the National Natural References
Science Foundation of China (82160577, 32000964),
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the Hainan Academician Innovation Center (Nanfan doi: 10.3390/biomimetics7030131
Medical Materials and Health Technology Innovation 2. Yang X, Wang Y, Zhou Y, et al. The application of
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polycaprolactone in three-dimensional printing scaffolds for
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Conflict of interest doi: 10.3390/polym13162754
The authors declare no financial and personal relationships 3. Mancuso E, Shah L, Jindal S, et al. Additively manufactured
with other entities or organizations that can inappropriately BaTiO(3) composite scaffolds: a novel strategy for load
influence the present work. They also have no professional bearing bone tissue engineering applications. Mater Sci Eng
or other personal interest of any nature or kind with any C Mater Biol Appl. 2021;126:112192.
product, service, and/or company that could be construed doi: 10.1016/j.msec.2021.112192
as influencing the position presented in, or the review of, 4. Gómez-Lizárraga KK, Flores-Morales C, Del Prado-Audelo
the current manuscript. ML, et al. Polycaprolactone- and polycaprolactone/ceramic-

Volume 11 Issue 4 (2025) 371 doi: 10.36922/IJB025210211