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International Journal of Bioprinting Sr-doped printed scaffolds for bone repair

Figure 13. Masson staining of the bone defect area of rats in each scaffold group. Arrows indicate area of new bone. Scale bars: 300 μm (top, 5×), 150
μm (bottom, 10×). Abbreviations: P, polycaprolactone (PCL); PSBP, polydopamine (PDA)/strontium (Sr)-doped bioactive glass (SrBG)/polycaprolactone
(PCL); SBP, strontium (Sr)-doped bioactive glass (SrBG)/polycaprolactone (PCL).

with other materials for better bone restoration. SrBG has for the largest proportion (approximately 38%) of the total,
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demonstrated certain advantages as a bone repair material which favors cell adhesion. In addition, functionalization of
due to its good osteogenic ability and immunomodulatory the material surface with PDA increases the hydrophilicity
properties. As displayed in Figure 3, SrBG comprises and surface adhesion of the material, thus effectively
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numerous uniformly arranged small spherical particles improving its biocompatibility. 39,47 Likewise, 3D printing
with a particle size distribution between 350 and 700 nm. technology can personalize the geometric shape of the
Among them, SrBG particles measuring 493.9 nm account scaffold according to the shape of the bone defect, allowing

Volume 11 Issue 4 (2025) 367 doi: 10.36922/IJB025210211