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Innovative Medicines & Omics A perspective on medicinal cannabis delivery systems

to develop cannabis-based formulations has shown to 4. De Backer B, Debrus B, Lebrun P, et al. Innovative
have several advantages over other formulations, such as development and validation of an HPLC/DAD method
increased efficacy, tumor targeting, and reduced systemic for the qualitative and quantitative determination of major
toxicity. However, each proposed formulation has been cannabinoids in cannabis plant material. J Chromatogr B
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using nanotechnology applicable to a specific cannabinoid 5. McPartland JM, Russo EB. Cannabis and cannabis extracts:
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6. Atakan Z. Cannabis, a complex plant: Different
None. compounds and different effects on individuals. Ther Adv
Funding Psychopharmacol. 2012;2(6):241-254.
doi: 10.1177/204512531245758
This research was funded by the Argentine National
Scientific and Technical Research Council (grant number 7. ElSohly MA, Slade D. Chemical constituents of marijuana:
PIBAA 2022-2023 28720210100304CO) and the National The complex mixture of natural cannabinoids. Life Sci.
2005;78(5):539-548.
Agency for the Promotion of Science and Technology
(grant number PICT-2021-I-INVI-00116). doi: 10.1016/j.lfs.2005.09.011
8. Grotenhermen F, Russo E, editors. Cannabis and
Conflict of interest Cannabinoids: Pharmacology, Toxicology, and Therapeutic

The authors declare that they have no known competing Potential. Binghamton, NY: Routledge; 2013.
financial interests or personal relationships that could have 9. Wright S, Wilkhu J. U.S. Patent No. 11,426,362. Washington,
appeared to influence the work reported in this paper. DC: U.S. Patent and Trademark Office; 2022.
10. Wilkhu J, Bender J. U.S. Patent Application No. 16/959,357.
Author contributions Washington, DC: U.S. Patent and Trademark Office; 2021.
Conceptualization: All authors 11. De Vries JA, Fernandez Cid MV, Heredia Lopez AM, Eiroa
Writing–original draft: All authors Martínez CM. U.S. Patent No. 10,245,237. Washington, DC:
Writing–review & editing: All authors U.S. Patent and Trademark Office; 2019.
Ethics approval and consent to participate 12. Sengupta A, Roychoudhury SK. Triglyceride composition of
Sesamum indicum seed oil. J Sci Food Agric. 1976;27(2):165-169.
Not applicable. doi: 10.1002/jsfa.2740270214
Consent for publication 13. Lv P, Zhang D, Guo M, et al. Structural analysis and
cytotoxicity of host-guest inclusion complexes of
Not applicable. cannabidiol with three native cyclodextrins. J Drug Deliv
Technol. 2019;51:337-344.
Availability of data
doi: 10.1016/j.jddst.2019.03.015
Not applicable.
14. Palrasu M, Wright L, Patel M, et al. Perspectives on
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