Page 99 - IMO-2-2

Innovative Medicines & Omics Femtomolar inhibition of pseudoeriocitrin

is needed to determine whether pseudoeriocitrin can be References
produced endogenously or through synthetic methods. 1. Kamb M, Roy S. Helminths, Soil-Transmitted. Travel-
This study offers novel insights into an inhibitor that Associated Infections & Diseases. CDC Yellow Book.
exhibits exceptional efficacy at the femtomolar level. United Kingdom: Oxford University Press; 2024. Available
This discovery may be significant for understanding the from: https://wwwnc.cdc.gov/travel/yellowbook/2024/
structure-activity relationship of the most potent inhibitors infections-diseases/helminths-soil-transmitted [Last
in the future. Moreover, this study is the first to showcase accessed on 2023 May 01].
the extraordinary inhibitory properties of a multi-radical 2. Giray H, Keskinoğlu P. Ilkokul öğrencilerinde Enterobius
molecule with a tetracyclic core structure through in silico vermicularis varliği ve etkileyen etmenler [The prevalence
analysis. of Enterobius vermicularis in schoolchildren and affecting
factors]. Turk Parazitol Derg. 2006;30(2):99-102.
Acknowledgments
3. Strelkauska A, Edwards A, Fahnert B, Pryor G, Strelkauskas J.
We would like to dedicate this paper to our esteemed Microbiology: A Clinical Approach. NY, USA: Garland
Professor, the late Prof. Dr. Metin Aktaş, who always lived Science; 2015.
with his unforgettable benevolence and elegance. doi: 10.1201/9780429258701

Funding 4. Karaman D. Prediction on the Anthelmintic Effects of Some
Herbal Ligands and Their Derivatives with In Silico Molecular
None. Modelling Method Doctoral Thesis. Bursa, Türkiye: Bursa
Uludag University; 2022.
Conflict of interest
5. Yelekçi K, Büyüktürk B, Kayrak N. In silico identification
The authors declare that they have no competing interests. of novel and selective monoamine oxidase B inhibitors.
J Neural Transm (Vienna). 2013;120(6):853-858.
Author contributions
doi: 10.1007/s00702-012-0954-0
Conceptualization: Dilara Karaman 6. Inoue T, Sugimoto Y, Masuda H, Kamei C. Antiallergic
Formal analysis: Dilara Karaman effect of flavonoid glycosides obtained from Mentha piperita
Investigation: Dilara Karaman L. Biol Pharm Bull. 2002;25(2):256-259.
Methodology: Dilara Karaman doi: 10.1248/bpb.25.256
Writing – original draft: Dilara Karaman
Writing – review & editing: All authors 7. Diab KA, Shafik RE, Yasuda S. In vitro Antioxidant and
antiproliferative activities of novel orange peel extract and
Ethics approval and consent to participate it’s fractions in leukemia HL-60 cells. Asian Pac J Cancer
Prev. 2015;16(16):7053-7060.
Not applicable.
doi: 10.7314/apjcp.2015.16.16.7053
Consent for publication 8. Guo G, Shi W, Shi F, et al. Anti-inflammatory effects of
eriocitrin against the dextran sulfate sodium-induced
Not applicable. experimental colitis in murine model. J Biochem Mol Toxicol.
Availability of data 2019;33(11):e22400.
doi: 10.1002/jbt.22400
Data supporting the findings are available on request from
the corresponding author. 9. Miyake Y, Yamamoto K, Osawa T. Isolation of eriocitrin
(eriodictyol 7-rutinoside) from lemon fruit (Citrus limon
Further disclosure BURM. F.) and its antioxidative activity. Food Sci Technol Int
Tokyo. 1997;3(1):84-89.
(i) Part of or the entire set of findings have been presented doi: 10.3136/fsti9596t9798.3.84
at the 4 International Eurasia Scientific Researches
th
and Innovation Congress, held on June 13–14, 2024 in 10. Ferreira PS, Manthey JA, Nery MS, Cesar TB.
Nakhchivan State University, Nakhchivan, Azerbaijan Pharmacokinetics and biodistribution of eriocitrin in rats.
under the title “A New in silico Observation on a J Agric Food Chem. 2012;69(6):1796-1805.
Virtual Molecule: Pseudoeriocitrin and Femtomolar doi: 10.1021/acs.jafc.0c04553
Inhibition in Molecular Dockings.” 11. Huey R, Morris GM, Olson AJ, Goodsell DS. Semiempirical
(ii) The paper has been uploaded to or deposited in a free energy force field with charge-based desolvation.
preprint server: https://doi.org/10.32388/C446VT.2 J Comput Chem. 2007;28(6):1145-1152.

Volume 2 Issue 2 (2025) 93 doi: 10.36922/imo.6026