Page 150 - ITPS-7-2

INNOSC Theranostics

and Pharmacological Sciences

CASE REPORT
Progression of pediatric febrile seizure to status

epilepticus: A case report

Mohammed Misbah Ul Haq *, Safa Hussain , Yaseen Farha , and
1
1
1
Swetha Parupugalla 2
1 Department of Pharmacy Practice, Deccan School of Pharmacy, Hyderabad, Telangana, India
2 Department of Pharmacy Practice, Bharat Institute of Technology, Hyderabad, Telangana, India

Abstract
Managing pediatric febrile seizures progressing into status epilepticus (SE) presents
challenges due to diagnostic complexities and the evolving nature of symptoms.
This case report presents the management of a 1-year-old pediatric patient who
experienced a febrile seizure progressing into SE. Laboratory findings reflected common
variations observed in febrile illnesses and seizures. Treatment comprised a multidrug
regimen involving antibiotics, anticonvulsants, and supportive care, primarily focused
on seizure control, infection management, and symptomatic relief, aligning with
established protocols for SE management in pediatric patients. However, the potential
for drug interactions, particularly with carbapenems, underscores the importance of
medication selection, especially in patients predisposed to seizures or neurological
complications. This case report emphasizes the necessity for a multidisciplinary
approach involving pediatricians, neurologists, and clinical pharmacists in optimizing
*Corresponding author: treatment strategies for SE. The involvement of clinical pharmacists in medication
Mohammed Misbah Ul Haq review, dosage adjustments, monitoring for drug interactions, and patient education
(drmdmisbah@outlook.com) played a pivotal role in achieving positive outcomes in this critical scenario. This
Citation: Misbah Ul Haq M, report sheds light on the complexities and challenges inherent in managing pediatric
Hussain S, Farha Y, Parupugalla S. febrile seizures advancing to SE and underscores the significance of collaborative,
Progression of pediatric febrile
seizure to status epilepticus: A multidisciplinary care in such cases.
case report. INNOSC Theranostics
and Pharmacological Sciences.
2024;7(2):2735. Keywords: Febrile status epilepticus; Pediatric seizures; Multi-drug regimen; Neurological
doi: 10.36922/itps.2735 complications
Received: January 14, 2024
Accepted: March 26, 2024
Published Online: April 26, 2024 1. Introduction
Copyright: © 2024 Author(s). Febrile seizures manifest as sudden convulsions triggered by a rapid elevation in body
This is an Open-Access article temperature, typically surpassing 38°C (100.4°F), without underlying seizure-inducing
distributed under the terms of the
Creative Commons Attribution conditions such as central nervous system infections, electrolyte imbalances, drug
License, permitting distribution, withdrawal, trauma, genetic predisposition, or known epilepsy. These seizures are
and reproduction in any medium, categorized as either simple or complex febrile seizures, with each subclassification
provided the original work is
properly cited. requiring distinct approaches and assessments. 1-3
Publisher’s Note: AccScience Febrile seizures often arise in conjunction with a temperature exceeding 38°C
Publishing remains neutral with (100.4°F) and in the absence of other seizure-provoking factors, although the convulsive
regard to jurisdictional claims in
published maps and institutional temperature threshold varies among individuals. They frequently coincide with the
affiliations rise in body temperature, serving as an early indication of an underlying illness, with

Volume 7 Issue 2 (2024) 1 doi: 10.36922/itps.2735