Page 61 - ITPS-7-2

INNOSC Theranostics

and Pharmacological Sciences

REVIEW ARTICLE
Addressing cortex dysregulation in youth

through brain health check coaching and
prophylactic brain development

Kenneth Blum 1,2,3,4,5,6,7,8,9,10 *, Eric R. Braverman , Mark S. Gold ,
2
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13
1
Catherine A. Dennen , David Baron , Panayotis K. Thanos , Colin
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Hanna , Igor Elman , Marjorie C. Gondre-Lewis , J. Wesson Ashford ,
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Andrew Newberg , Margaret A. Madigan , Nicole Jafari 5,18 , Foojan Zeine 18,19 ,
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Keerthy Sunder 20,21 , John Giordano , Debmayla Barh , Ashim Gupta ,
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Paul Carney , Abdalla Bowirrat , and Rajendra D. Badgaiyan *
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4
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1 Division of Addiction Research and Education, Center for Sports, Exercise and Global Mental
Health, Western University of Health Sciences, Pomona, California, United States of America
2 The Kenneth Blum Behavioral and Neurogenetic Institute LLC, Austin, Texas, United States of America
3 Faculty of Education and Psychology, Institute of Psychology, Eötvös Loránd University Budapest,
Budapest, Hungary
4 Department of Molecular Biology and Adelson School of Medicine, Ariel University, Ariel, Israel
5 Division of Personalized Medicine, Cross-Cultural Research and Educational Institute, San
Clemente, California, United States of America
Abstract
*Corresponding authors:
Kenneth Blum The Carter Center has estimated that the addiction crisis in the United States (US), if
(drd2gene@gmail.com) continues to worsen at the same rate, may cost the country approximately 16 trillion
Rajendra D. Badgaiyan
(badgaiyan@gmail.com) dollars by 2030. In recent years, the well-being of youth has been compromised by not
only the coronavirus disease 2019 pandemic but also the alarming global opioid crisis,
Citation: Blum K, Braverman ER, particularly in the US. Each year, deadly opioid drugs claim hundreds of thousands of
Gold MS, et al. Addressing cortex
dysregulation in youth through lives, contributing to an ever-rising death toll. In addition, maternal usage of opioids
brain health check coaching and and other drugs during pregnancy could compromise the neurodevelopment of
prophylactic brain development. children. A high rate of DNA polymorphic antecedents compounds the occurrence of
INNOSC Theranostics and
Pharmacological Sciences. epigenetic insults involving methylation of specific essential genes related to normal
2024;7(2):1472. brain function. These genetic antecedent insults affect healthy DNA and mRNA
doi: 10.36922/itps.1472
transcription, leading to a loss of proteins required for normal brain development
Received: August 8, 2023 and function in youth. Myelination in the frontal cortex, a process known to extend
Accepted: February 21, 2024 until the late 20s, delays the development of proficient executive function and
decision-making abilities. Understanding this delay in brain development, along with
Published Online: April 30, 2024
the presence of potential high-risk antecedent polymorphic variants or alleles and
Copyright: © 2024 Author(s). generational epigenetics, provides a clear rationale for embracing the Brain Research
This is an Open Access article Commission’s suggestion to mimic fitness programs with an adaptable brain health
distributed under the terms of the
Creative Commons Attribution check (BHC). Implementing the BHC within the educational systems in the US and
License, permitting distribution, other countries could serve as an effective initiative for proactive therapies aimed
and reproduction in any medium, at reducing juvenile mental health problems and eventually criminal activities,
provided the original work is
properly cited. addiction, and other behaviors associated with reward deficiency syndrome.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Brain health check; Cognition; Dopaminergic dysregulation; Executive
regard to jurisdictional claims in
published maps and institutional function; Reward deficiency syndrome; Genetics; Epigenetics
affiliations.

Volume 7 Issue 2 (2024) 1 doi: 10.36922/itps.1472