Page 82 - ITPS-7-3
P. 82
INNOSC Theranostics and
Pharmacological Sciences Enhancers and SEs in cancer treatment
51. Sabari BR, Dall’Agnese A, Boija A, et al. Coactivator enhancers lead waves of coordinated transcription
condensation at super-enhancers links phase separation and in transitioning mammalian cells. Science. 2015;
gene control. Science. 2018;361(6400):eaar3958. 347(6225):1010-1014.
doi: 10.1126/science.aar3958 doi: 10.1126/science.1259418
52. Cerne F. Hospitals not immune to high cost of stress. 63. Pefanis E, Wang J, Rothschild G, et al. RNA exosome-
Hospitals. 1988;62(19):69-70. regulated long non-coding RNA transcription controls
super-enhancer activity. Cell. 2015;161(4):774-789.
53. Bakshi S, McKee C, Walker K, Brown C, Chaudhry GR.
Toxicity of JQ1 in neuronal derivatives of human doi: 10.1016/j.cell.2015.04.034
umbilical cord mesenchymal stem cells. Oncotarget. 64. Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C,
2018;9(73):33853-33864.
Kim TK. Enhancer RNA facilitates NELF release from
doi: 10.18632%2Foncotarget.26127 immediate early genes. Mol Cell. 2014;56(1):29-42.
54. Mohammed Ismail W, Mazzone A, Ghiraldini FG, et al. doi: 10.1016/j.molcel.2014.08.023
MacroH2A histone variants modulate enhancer activity to 65. Onoguchi M, Hirabayashi Y, Koseki H, Gotoh Y.
repress oncogenic programs and cellular reprogramming. A noncoding RNA regulates the neurogenin1 gene locus
Commun Biol. 2023;6(1):215.
during mouse neocortical development. Proc Natl Acad Sci
doi: 10.1038/s42003-023-04571-1 U S A. 2012;109(42):16939-16944.
55. Fang MY, Markmiller S, Vu AQ, et al. Small-molecule doi: 10.1073/pnas.1202956109
modulation of TDP-43 recruitment to stress granules 66. Lam MT, Li W, Rosenfeld MG, Glass CK. Enhancer RNAs
prevents persistent TDP-43 accumulation in ALS/FTD. and regulated transcriptional programs. Trends Biochem Sci.
Neuron. 2019;103(5):802-819.e11.
2014;39(4):170-182.
doi: 10.1016/j.neuron.2019.05.048
doi: 10.1016/j.tibs.2014.02.007
56. Napoli S, Munz N, Guidetti F, Bertoni FJ. Enhancer 67. Melo CA, Drost J, Wijchers PJ, et al. eRNAs are required for
RNAs (eRNAs) in cancer: The jacks of all trades. Cancers. p53-dependent enhancer activity and gene transcription.
2022;14(8):1978.
Mol cell. 2013;49(3):524-535.
doi: 10.3390/cancers14081978
doi: 10.1016/j.molcel.2012.11.021
57. Olmedo-Suárez MÁ, Ramírez-Díaz I, Pérez-González A, 68. Mousavi K, Zare H, Dell’Orso S, et al. eRNAs promote
et al. Epigenetic regulation in exposome-induced transcription by establishing chromatin accessibility at
tumorigenesis: Emerging roles of ncRNAs. Biomolecules. defined genomic loci. Mol cell. 2013;51(5):606-617.
2022;12(4):513.
doi: 10.1016/j.molcel.2013.07.022
doi: 10.3390/biom12040513
69. Lam MT, Cho H, Lesch HP, et al. Rev-Erbs repress
58. Pérez-González A, Ramírez-Díaz I, Guzmán-Linares J, macrophage gene expression by inhibiting enhancer-
Sarvari P, Sarvari P, Rubio KJ. ncRNAs orchestrate directed transcription. Nature. 2013;498(7455):511-515.
chemosensitivity induction by neddylation blockades.
Cancers (Basel). 2024;16(4):825. doi: 10.1038/nature12209
doi: 10.3390/cancers16040825 70. Chen H, Liang H. A high-resolution map of human enhancer
RNA loci characterizes super-enhancer activities in cancer.
59. Niderla-Bielińska J, Jankowska-Steifer E, Włodarski PJ. Cancer Cell. 2020;38(5):701-715.
Non-coding RNAs and human diseases: Current status and
future perspectives. Int J Mol Sci. 2023;24(14):11679. doi: 10.1016/j.ccell.2020.08.020
doi: 10.3390/ijms241411679 71. Zhu Y, Sun L, Chen Z, Whitaker JW, Wang T, Wang W.
Predicting enhancer transcription and activity from
60. Chen B, Dragomir MP, Yang C, et al. Targeting non- chromatin modifications. Nucleic Acids Res. 2013;
coding RNAs to overcome cancer therapy resistance. Signal 41(22):10032-10043.
Transduct Target Ther. 2022;7(1):121.
72. Mikhaylichenko O, Bondarenko V, Harnett D, et al. The
doi: 10.1038/s41392-022-00975-3
degree of enhancer or promoter activity is reflected by the
61. Andersson R, Gebhard C, Miguel-Escalada I, et al. An atlas levels and directionality of eRNA transcription. Genes Dev.
of active enhancers across human cell types and tissues. 2018;32(1):42-57.
Nature. 2014;507(7493):455-461.
doi: 10.1101/gad.308619.117
doi: 10.1038/nature12787
73. Melgar MF, Collins FS, Sethupathy P. Discovery of active
62. Arner E, Daub CO, Vitting-Seerup K, et al. Transcribed enhancers through bidirectional expression of short
Volume 7 Issue 3 (2024) 11 doi: 10.36922/itps.3654

