Page 81 - ITPS-7-3

INNOSC Theranostics and
Pharmacological Sciences Enhancers and SEs in cancer treatment

mammalian genomes identified by analysis of chromatin 39. Jia Y, Zhou J, Tan TK, et al. Super enhancer-mediated
interactions. Nature. 2012;485(7398):376-380. upregulation of HJURP promotes growth and survival
of t (4; 14)-positive multiple myeloma. Cancer Res.
doi: 10.1038/nature11082
2022;82(3):406-418.
28. Giorgio E, Robyr D, Spielmann M, et al. A large genomic
deletion leads to enhancer adoption by the lamin B1 doi: 10.1158/0008-5472.CAN-21-0921
gene: A second path to autosomal dominant adult-onset 40. Kelly MR, Wisniewska K, Regner MJ, et al. A multi-omic
demyelinating leukodystrophy (ADLD). Hum Mol Genet. dissection of super-enhancer driven oncogenic gene
2015;24(11):3143-3154. expression programs in ovarian cancer. Nat Commun. 2022;
13(1):4247.
doi: 10.1093/hmg/ddv065
doi: 10.1038/s41467-022-31919-8
29. Lupiáñez DG, Kraft K, Heinrich V, et al. Disruptions of
topological chromatin domains cause pathogenic rewiring 41. Neumayr C, Haberle V, Serebreni L, et al. Differential
of gene-enhancer interactions. Cell. 2015;161(5):1012-1025. cofactor dependencies define distinct types of human
enhancers. Nature. 2022;606(7913):406-413.
doi: 10.1016/j.cell.2015.04.004
doi: 10.1038/s41586-022-04779-x
30. Lupiáñez DG, Spielmann M, Mundlos S. Breaking TADs:
How alterations of chromatin domains result in disease. 42. Zhang J, Yue W, Zhou Y, Liao M, Chen X, Hua J. Super
Trends Genet. 2016;32(4):225-237. enhancers-functional cores under the 3D genome. Cell
Prolif. 2021;54(2):e12970.
doi: 10.1016/j.tig.2016.01.003
doi: 10.1111/cpr.12970
31. Akdemir KC, Le VT, Chandran S, et al. Disruption of chromatin
folding domains by somatic genomic rearrangements in 43. Benecke AG, Eilebrecht SJ. RNA-mediated regulation of
human cancer. Nat Genet. 2020;52(3):294-305. HMGA1 function. Biomolecules. 2015;5(2):943-957.
doi: 10.1038/s41588-019-0564-y doi: 10.3390/biom5020943
32. Flavahan WA, Drier Y, Liau BB, et al. Insulator dysfunction 44. Yang Z, Yik JH, Chen R, et al. Recruitment of P-TEFb
and oncogene activation in IDH mutant gliomas. Nature. for stimulation of transcriptional elongation by the
2016;529(7584):110-114. bromodomain protein Brd4. Mol Cell. 2005;19(4):535-545.
doi: 10.1038/nature16490 doi: 10.1016/j.molcel.2005.06.029
33. Ji X, Dadon DB, Powell BE, et al. 3D chromosome regulatory 45. Dong J, Li J, Li Y, Ma Z, Yu Y, Wang CY. Transcriptional super-
landscape of human pluripotent cells. Cell Stem Cell. enhancers control cancer stemness and metastasis genes in
2016;18(2):262-275. squamous cell carcinoma. Nat Commun. 2021;12(1):3974.
doi: 10.1016/j.stem.2015.11.007 doi: 10.1038/s41467-021-24137-1
34. Whyte WA, Orlando DA, Hnisz D, et al. Master transcription 46. Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA.
factors and mediator establish super-enhancers at key cell A phase separation model for transcriptional control. Nat
identity genes. Cell. 2013;153(2):307-319. Commun. 2021;12(1):3974.
doi: 10.1016/j.cell.2013.03.035 47. Hnisz D, Abraham BJ, Lee TI, et al. Super-enhancers in the
control of cell identity and disease. Cell. 2013;155(4):934-947.
35. Koutsi MA, Pouliou M, Champezou L, et al. Typical
enhancers, super-enhancers, and cancers. Cancers (Basel). doi: 10.1016/j.cell.2013.09.053
2022;14(18):4375.
48. Holehouse AS, Pappu RV. Functional implications
doi: 10.3390/cancers14184375 of intracellular phase transitions. Biochemistry. 2018;
57(17):2415-2423.
36. Yoshino S, Suzuki HI. The molecular understanding of
super-enhancer dysregulation in cancer. Nagoya J Med Sci. doi: 10.1021/acs.biochem.7b01136
2022;84(2):216.
49. Grosveld F, Van Staalduinen J, Stadhouders R.
doi: 10.18999/nagjms.84.2.216 Transcriptional regulation by (super) enhancers: From
discovery to mechanisms. Annu Rev Genomics Hum Genet.
37. See YX, Chen K, Fullwood MJ. MYC overexpression leads
to increased chromatin interactions at super-enhancers and 2021;22(1):127-146.
MYC binding sites. Genome Res. 2022;32(4):629-642. doi: 10.1146/annurev-genom-122220-093818
doi: 10.1101/gr.276313.121 50. Ryu K, Park G, Cho WK. Emerging insights into
transcriptional condensates. Exp Mol Med. 2024;56:820-826.
38. Di Palma J. ERC cholecystography. J Clin Gastroenterol.
1988;10(1):117-118. doi: 10.1038/s12276-024-01228-9

Volume 7 Issue 3 (2024) 10 doi: 10.36922/itps.3654