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INNOSC Theranostics and
Pharmacological Sciences Transformative natural product-drug combinations

A B

C

Figure 5. Attenuated total reflectance-Fourier transform infrared spectroscopy spectra of guava extract (A), aspirin (B), and guava-aspirin mixture (C).
Image reproduced with permission from Gideon. 26

method can be further explored by reacting non-bioactive Acknowledgments
constituents of one plant extract with those of another,
bioactive constituents of one plant with non-bioactive None.
constituents of another, or using different solvents and Funding
isolated compounds. Various combinatorial reactions can
be designed to achieve the desired outcomes. None.
3. Conclusion Conflict of interest
This review outlines strategies for leveraging plant extracts in The author declares no competing interests.
the fight against drug resistance. Functional group analysis,
GC-MS data, and antimicrobial screenings from various Author contributions
sources demonstrate that combining plant extracts with This is a single-authored article.
drugs or other structurally functional reagents can induce
significant structural and functional changes, resulting in Ethical approval and consent to participate
the formation of intermediate or new compounds. These
compounds may act individually or synergistically to combat Not applicable.
multi-drug-resistant bacteria. For instance, the GC-MS
analysis identified potent anticancer properties, suggesting Consent for publication
that these combinations may also offer therapeutic potential Not applicable.
in antifungal, anti-inflammatory, antiviral, and anticancer
applications, potentially yielding positive outcomes Availability of data
similar to the observed antibacterial effects. Therefore, this Not applicable.
approach holds significant promise and warrants further
exploration using advanced synthetic methods and tools to Further disclosure
optimize drug discovery and development. By harnessing
the potential of plant extracts and employing sophisticated The paper has been deposited in the preprint server
techniques, we can develop novel treatments to effectively Chemrxiv.com under the DOI: 10.26434/chemrxiv-2024-
address the growing challenge of drug resistance. 0kks1-v2.

Volume 8 Issue 2 (2025) 93 doi: 10.36922/itps.4068