Page 20 - JCBP-1-1

Journal of Clinical and
Basic Psychosomatics Smoking and schizophrenia symptoms

Table 1. The studies related to SCZ symptoms and smoking found in Pubmed
Study Goal of study Main relevant results
Nicotine reverses hypofrontality in animal models of The question of whether nicotine can Administering nicotine could
addiction and SCZ [24] modify hypofrontality in addiction and potentially serve as a therapeutic
SCZ models remains unresolved. approach for treating SCZ.
Nicotine in action: Cigarette smoking modulated SCZ patients and healthy subjects Smoking affects the regulation of
homotopic functional connectivity in SCZ [43] who smoked had deficits between hemispheric connectivity.
hemispheres.
A temporal chronnectomic framework: Cigarette Smoking-related alterations on the Found a smoking-related
smoking preserved the prefrontal dysfunction in SCZ [44] prefrontal dynamics of information preservation effect on disrupted
integration were different between the prefrontal dynamics.
control and SCZ.
Self-reported motivation to smoke in SCZ is related to Compared smoking motivation in APs may influence smoking
AP drug treatment [36] controls and SCZ patients. motivation.
Minimal effects of prolonged smoking abstinence or The self-medication hypothesis by No changes in cognitive test
resumption on cognitive performance challenge the examining the effects of smoking performance with smoking
“self-medication” hypothesis in SCZ [45] abstinence and resumption on cognition cessation.
in SCZ patients.
Tobacco smoking in treatment-resistant SCZ patients Compared cognitive performance, Smoking was not associated with
is associated with impaired cognitive functioning, psychotic symptoms, and social better cognitive performances in
more severe negative symptoms, and poorer social adjustment between tobacco-smoking SCZ patients.
adjustment [17] TRS patients and non-smoking TRS
patients.
Cognitive performance and smoking in first-episode The relationship between smoking and Smoking might improve attention
psychosis: The self-medication hypothesis [25] symptoms/side effects of medication. and working memory.
Tobacco smoking is associated with AP medication, The clinical characteristics of smoking Patients with tobacco use have
physical aggressiveness, and alcohol use disorder in SCZ: in SCZ. therapeutic specificities.
results from the FACE-SZ national cohort [46]
A test of the cognitive self-medication hypothesis of Tested predictions of the cognitive self- Subjective or objective attentional
tobacco smoking in SCZ [47] medication hypothesis. benefits are unlikely the critical
force of smoking.
Self-reported motivation to smoke in SCZ is related to Evaluated smoking motivation in controls SCZ patients reported a stronger
AP drug treatment [36] and SCZ patients. motivation to smoke than controls
for reasons related to pleasure
from smoking and the need for
psychomotor stimulation.
Minimal effects of prolonged smoking abstinence or Examined the effects of smoking There were no effects of early
resumption on cognitive performance challenge the abstinence on cognition. abstinence from smoking on
“self-medication” hypothesis in SCZ [45] cognitive measures in smokers with
SCZ.
SCZ and smoking: An epidemiological survey in a state Examined whether smoking is related to SCZ may increase the risk of being
hospital [48] SCZ. a heavy smoker.
Tobacco smoking is causally associated with AP In smokers, heterozygotes and Smoking could influence psychosis
medication use and SCZ, but not with antidepressant homozygotes for rs1051730 genotype development.
medication use or depression [30] had higher smoking intensity than non-
carriers.
Effects of nicotine on social cognition, social Examined the effect of nicotine on social No effects of nicotine by enhanced
competence, and self-reported stress in SCZ patients and cognition in SCZ. recognition of facial affect.
healthy controls [49]
Alpha7 nicotinic acetylcholine receptors modulate The study aimed to investigate whether Found a reduction of α7 nAChR
motivation to self-administer nicotine: Implications for blocking α7 nAC1 would enhance the function as a mechanism for
smoking and SCZ [50] motivation of rats to self-administer increased tobacco use in SCZ.
nicotine during reinforcement.
Use of tobacco in SCZ: A double-edged sword [51] Examined the associations between Supports the self-medication
tobacco and susceptibility to SCZ. hypothesis.
(Cont’d...)

Volume 1 Issue 1 (2023) 3 https://doi.org/10.36922/jcbp.1014