Page 22 - JCBP-1-1

Journal of Clinical and
Basic Psychosomatics Smoking and schizophrenia symptoms

Table 1. (Continued)
Study Goal of study Main relevant results
Is smoking linked to positive symptoms in acutely ill The relationship between smoking and In psychiatric patients, smoking is
psychiatric patients? [31] positive symptoms. linked with positive symptoms.
Effects of tobacco smoking and schizotypal personality EEG recorded from smokers and The changes in spontaneous
on spectral contents of spontaneous EEG [60] non-smokers students were studied by EEG-as attributed to smoking-were
parametric spectral estimation. observed in the occipital region for
groups of high and low schizotypy
participants.
Initial phase 2 trial of a nicotinic agonist in SCZ [33] The agent 3-(2,4-dimethoxybenzylidene) DMXB-A that activates alpha-7
anabaseine is a partial alpha(7)-nicotinic nicotinic receptors, improved clinical
agonist. ratings of negative symptoms.
Serotonin transporter genotype and depressive Assessed the effects of NRT on SWM Smoking-deprived smokers
symptoms moderate effects of nicotine on spatial concerning depressive traits and d5-HTT completed the dot recall test of
working memory [61] genotype. SWM during counterbalanced and
double-blind nicotine and placebo
testing sessions.
Lack of beneficial galantamine effect for smoking Investigated galantamine’s effect on Galantamine did not demonstrate
behavior: A double-blind randomized trial in people smoking in people who were smokers. a beneficial effect on smoking
with SCZ [62] behavior.
Nicotine-haloperidol interactions and cognitive Investigated the interactions of Nicotine may improve cognitive
performance in schizophrenics [63] haloperidol and nicotine on cognition of performance.
SCZ patients.
Nicotine is more addictive, not more cognitively Used a neurodevelopmental model of Developmental cortical temporal
therapeutic in a neurodevelopmental model of SCZ mental illness in rats to test whether limbic dysfunction may amplify
produced by neonatal ventral hippocampal lesions [11] nicotine dependence pervades mental nicotine’s reinforcing effects.
illness.
Chronic nicotine improves cognitive performance Examined procognitive effects of Nicotine had procognitive effects.
in a test of attention but does not attenuate cognitive nicotine in a model of SCZ-like cognitive
disruption induced by repeated phencyclidine dysfunction to test self-medication
administration [64] hypothesis.
Chronic nicotine improves short-term memory Examined the effects of long-term Nicotine improves cognitive
selectively in a G72 mouse model of SCZ [65] nicotine on cognition in an animal model symptoms by facilitating nicotine-
of SCZ susceptibility. induced α7nACh receptor
activation.
A comparison of smoking behaviors between patients Investigated if there is a difference in According to measurements
treated with clozapine and depot neuroleptics [66] smoking behavior between patients of expired CO levels, patients
treated with clozapine and depot treated with clozapine smoke less
neuroleptics. than patients treated with depot
neuroleptics.
Nicotine and clozapine effects on attentional In cognitive impairment of SCZ with the Supported in the study by the
performance impaired by the NMDA antagonist NMDA antagonist dizocilpine, the effects reversal of the dizocilpine-induced
dizocilpine in female rats [67] of clozapine and nicotine on impaired attentional impairment by nicotine.
attentional hit accuracy were examined.
Adolescent nicotine sensitization and effects of nicotine Reported neonatal quinpirole treatment Neonatal quinpirole boosted
on accumbal dopamine release in a rodent model of of rats with a D(2)/D(3) agonist increases adolescent nicotine sensitization,
increased dopamine D2 receptor sensitivity [68] dopamine D(2) receptor sensitivity, which accumbal dopamine overflow,
persists throughout their lifetime. and BDNF protein in response to
nicotine.
Schizophrenic patients who smoke have a faster finger- The hypothesis was tested by investigating Smokers showed faster finger-
tapping rate than non-smokers [69] the correlation between smoking status tapping rates than non-smokers.
and finger-tapping rate.
Nicotine dependence and symptoms in SCZ: Naturalistic High positive symptoms were less Suggest a complex interaction
study of complex interactions [70] frequent in mildly dependent smokers between nicotine dependence and
than in non-smokers. nicotine dependence and SCZ
symptoms.
(Cont’d...)

Volume 1 Issue 1 (2023) 5 https://doi.org/10.36922/jcbp.1014