Page 55 - JCBP-1-1

Journal of Clinical and

Basic Psychosomatics

CASE REPORT
Comorbid psychiatric disorders in a Crouzon

syndrome patient: A case report

3
Shuangyan Li 1,2† , Chong Tang 1,2† , Yang Zhou , Yue Gu , Xian Luo , Yan Xu ,
1,2
1,2
1,2
and Bin Zhang *
1,2
1 Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University,
Guangzhou, China
2 Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired
Intelligence, Southern Medical University, Guangzhou, China
3 Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, China

Abstract
Crouzon syndrome (CS) is a craniofacial disorder inherited in autosomal dominant
manner. CS patients could present with prominent psychiatric symptoms, but few
could be diagnosed with the symptoms in the psychiatry department during the
first medical consultation. The patients’ emotional needs and mental health were
often neglected. We reported a case of a 15-year-old girl diagnosed with psychiatric
disorders during the first medical consultation in the psychiatry department since
birth, presenting with characteristic features of CS, including exophthalmos, facial
anomalies, and mandibular prognathism. The psychiatric symptoms were improved
† These authors contributed equally obviously through administering appropriate treatment. This case report emphasizes
to this work. the importance of CS patients’ mental health and family’s emotional support.
*Corresponding author:
Bin Zhang
(zhang73bin@hotmail.com) Keywords: Crouzon syndrome; Psychological disorder; Craniofacial dysostosis;
Craniosynostosis; Stupor
Citation: Li S, Tang C, Zhou Y,
et al., 2023, Comorbid psychiatric
disorders in a Crouzon syndrome
patient: A case report. Journal of
Clinical and Basic Psychosomatics, 1. Background
1(1): 0405.
https://doi.org/10.36922/jcbp.0405 Crouzon syndrome (CS), also known as craniofacial dysostosis, is one of the
Received: April 6, 2023 craniosynostosis syndromes, accounting for nearly 4.8% of them at birth. In 1912, this
syndrome was described by the French physician Louis Edouard Octave Crouzon for
Accepted: May 18, 2023
the first time . It is a rare genetic disorder belonging to an autosomal dominant genetic
[1]
Published Online: June 8, 2023 condition. CS is caused by a sporadic occurrence or familial aggregation of mutations in
Copyright: © 2023 Author(s). the fibroblast growth factor receptor 2 (FGFR2) gene and is characterized by craniofacial
This is an Open-Access article dysostosis, exophthalmos, and facial anomalies with the hypoplastic maxilla and relative
distributed under the terms of the
Creative Commons Attribution mandibular prognathism. Upper airway obstruction, vision loss, and hearing loss could
License, permitting distribution, occur in patients with CS .
[2]
and reproduction in any medium,
provided the original work is CS is different from other craniosynostosis syndromes (Apert syndrome, Carpenters
properly cited. syndrome, Saethre-Chotzen syndrome, and Pfeiffer syndrome), where patients with CS
[3]
Publisher’s Note: AccScience have normal hands and feet and a lower incidence of intellectual disabilities. However,
Publishing remains neutral with it has been reported that craniosynostosis could cause intracranial hypertension,
regard to jurisdictional claims in [4,5]
published maps and institutional further damaging brain development and leading to mental retardation . Due
affiliations. to the special facial features, CS patients usually make the first medical visit to the

Volume 1 Issue 1 (2023) 1 https://doi.org/10.36922/jcbp.0405