Page 18 - JCBP-2-1

Journal of Clinical and
Basic Psychosomatics MRI and functional constipation

4. Conclusion Hu, Wenchao Zhang, Weibin Ji
Writing – review & editing: Yi Zhang, Yongzhan Nie,
Neuroimaging studies have unveiled functional and Yonghuan Feng
structural abnormalities in brain regions and networks
responsible for regulating emotions, motor control, and Ethics approval and consent to participate
somatic sensation in patients with FC. These changes
demonstrate correlations with somatic symptoms, Not applicable.
psychiatric factors, and gender effects. The attributes of Consent for publication
WM microstructure and networks reflect the brain’s ability
for information dissemination and functional integration, Not applicable.
offering further insights into the abnormal physiological
and psychological behaviors observed in patients with Availability of data
FC. The interplay between alterations in structure and Not applicable.
function, along with the presence of anxiety and depression,
underscores the important role of psychiatric factors in the References
onset and progression of FC. Furthermore, gender-related 1. Aziz I, Whitehead WE, Palsson OS, et al., 2020, An approach
differences in brain regions mainly involved in emotional to the diagnosis and management of Rome IV functional
processing and visceral perception contribute to the disorders of chronic constipation. Expert Rev Gastroenterol
heightened susceptibility of female patients to the negative Hepatol, 14: 39–46.
effects of mental factors and constipation symptoms. https://doi.org/10.1080/17474124.2020.1708718
This comprehensive review reveals that FC is associated 2. Mugie SM, Benninga MA, Di Lorenzo C, 2011, Epidemiology
with dysfunction and structural abnormalities, providing of constipation in children and adults: A systematic review.
imaging evidence and a theoretical basis for exploring the Best Pract Res Clin Gastroenterol, 25: 3–18.
pathological mechanism underlying FC. It also facilitates https://doi.org/10.1016/j.bpg.2010.12.010
an examination of the influence of psychiatric and gender
factors on the condition, steering the direction of effective 3. Milosavljevic T, Popovic DD, Mijac DD, et al., 2022, Chronic
treatment and preventive strategies. constipation: Gastroenterohepatologist’s approach. Dig Dis,
40: 175–180.
Acknowledgments https://doi.org/10.1159/000516976
None. 4. Drossman DA, 2016, Functional Gastrointestinal Disorders:
History. Pathophysiology, Clinical Features and Rome IV.
Funding Gastroenterology, 19:S0016-5085(16)00223-7.
This work was supported by the National Natural Science https://doi.org/10.1053/j.gastro.2016.02.032
Foundation of China (grant numbers: 82172023 and 5. Barberio B, Judge C, Savarino EV, et al., 2021, Global
82202252); National Key R&D Program of China (grant prevalence of functional constipation according to the
number: 2022YFC3500603); the Fundamental Research Rome criteria: A systematic review and meta-analysis.
Funds for the Central Universities (grant numbers: Lancet Gastroenterol Hepatol, 6: 638–648.
ZYTS23188, XJSJ23190, XJS221201, and QTZX23093); https://doi.org/10.1016/S2468-1253(21)00111-4
Natural Science Basic Research Program of Shaanxi (grant
numbers: 2022JC-44, 2022JQ-622, 2023-JC-QN-0922, and 6. Pinto-Sanchez MI, Ford AC, Avila CA, et al., 2015, Anxiety
2023-ZDLSF-07). and depression increase in a stepwise manner in parallel
with multiple FGIDs and symptom severity and frequency.
Conflict of interest Am J Gastroenterol, 110: 1038–1048.
https://doi.org/10.1038/ajg.2015.128
The authors declare that they have no competing interest.
7. Dong YY, Chen FX, Yu YB, et al., 2013, A school-based
Author contributions study with Rome III criteria on the prevalence of functional
gastrointestinal disorders in Chinese college and university
Conceptualization: Yi Zhang, Yongzhan Nie, Yonghuan students. PLoS One, 8: e54183.
Feng
Supervision: Huiling Zhou, Zhao Yan, Zaichen La, https://doi.org/10.1371/journal.pone.0054183
Mengshan Li 8. De Winter BY, Deiteren A, De Man JG, 2016, Novel nervous
Writing – original draft: Yonghuan Feng, Guanya Li, Yang system mechanisms in visceral pain. Neurogastroenterol

Volume 2 Issue 1 (2024) 10 https://doi.org/10.36922/jcbp.1463