Page 14 - JCBP-2-1

Journal of Clinical and
Basic Psychosomatics MRI and functional constipation

A

B C

D E

Figure 3. Results of sMRI studies. (A) Brain regions represented altered morphometry in FC patients compared to HC . (B) TBSS analysis showed
[59]
significantly decreased FA (first row, red-yellow), increased MD (second row, blue-light blue), and increased RD (third row, blue-light blue) in multiple
brain regions in patients with FC compared to HC . (C) Regions showed significant differences in nodal degree and efficiency. The blue nodes represent
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the value of FC < HC and the yellow nodes represent the value of FC > HC . (D) Fibers showed decreased FA values in FC patients relative to HC .
[70]
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(E) Fibers showed increased RD and MD in FC patients compared to HC . The abbreviations of the 90 brain regions are given in the Appendix.
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Abbreviations: fMRI: Functional magnetic resonance imaging; TBSS: Tract-based spatial statistics; FD: Fractional anisotropy, MD: Mean diffusivity,
RD: Radial diffusivity, FC: Functional constipation; HC: Healthy controls.
the OFC, involved in sensory integration and decision- that was negatively associated with anxiety . The posterior
[30]
making , indicated abnormal emotional processing, insula (pINS), responsible for receiving somatic and
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shedding light on why the majority of patients with FC visceral information and transmitting it to the aINS, which
[40]
present with depressive-associated symptoms. Additionally, integrates it with emotional information , suggested
a study reported that FC_F had higher RSFC of PreCen/ significant gender differences in perceiving visceral stimuli
PostCen (postcentral gyrus)-INS than FC_M, a correlation and regulating emotions.
that was positively associated with abdominal pain. FC_F To gain a deeper understanding of the directional
also exhibited lower RSFC of INS-lateral OFC, a finding causal relationships between different brain regions,

Volume 2 Issue 1 (2024) 6 https://doi.org/10.36922/jcbp.1463