Page 44 - JCBP-2-1

Journal of Clinical and

Basic Psychosomatics

ORIGINAL RESEARCH ARTICLE
Correlations between depressive disorder,

obstructive sleep apnea, and hypothalamic
inflammation

Guanzhong Dong , Xuanyan Zhu , Qiaoyang Zhang , Yuwen Jiao , Yi Ma ,
3
2
1
1†
1†
Shumin Zhu , Lihao Zhang , Min Zhang , Liming Tang *, and Yin Cao *
1
1
2
1
4
1 Department of Psychology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical
University, Changzhou, 231000, China
2 Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People’s Hospital of
Nanjing Medical University, Changzhou, 231000, China
3 Department of Radiology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical
University, Changzhou, 231000, China
4 Department of Neurology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical
University, Changzhou, 231000, China
Abstract
† These authors contributed equally Obesity is a significant public health concern in China, with a 2.5-fold increase
to this work. in prevalence over the past 30 years. This increase corresponds to a rise in the
*Corresponding authors: prevalence of obstructive sleep apnea (OSA). This study aims to investigate the
Liming Tang associations of OSA with depressive disorders and hypothalamic inflammation
(tangliming@njmu.edu.cn)
Yin Cao in obese young men. Between January 2020 and December 2021, 62 obese
(czcaoyin@163.com) male patients were selected and divided into two groups: a depressive disorder
Citation: Dong G, Zhu X, Zhang Q, group (18 cases) and a non-depressive disorder group (44 cases) according to the
et al., 2024, Correlations between diagnostic criteria of the DSM-5 combined with depressive disorder. All patients
depressive disorder, obstructive were monitored using a portable sleep monitor. Hypothalamic inflammation was
sleep apnea, and hypothalamic
inflammation. J Clin Basic evaluated using quantitative magnetic resonance imaging (MRI) by calculating
Psychosom, 2(1): 1040. the signal intensity (SI) ratio of the T2-weighted phase of the hypothalamus/
https://doi.org/10.36922/jcbp.1040
amygdala (H/A). Differences were observed in the respiratory event index
Received: June 4, 2023 (REI), lowest oxygen saturation, and oxygen desaturation index (P < 0.05).
Accepted: September 12, 2023 In the depressive disorder group, the left H/A was significantly higher than in
the non-depressive disorder group (P = 0.002), whereas the right H/A did not
Published Online: October 26,
2023 differ significantly between the two groups (P > 0.05). Furthermore, the left H/A
exhibited correlations with REI and body mass index (BMI) (P < 0.05), while no
Copyright: © 2023 Author(s).
This is an Open-Access article correlation was found between the right H/A and AHI (P > 0.05). In conclusion, our
distributed under the terms of the findings suggest that the left hypothalamic inflammation is positively correlated
Creative Commons Attribution
License, permitting distribution, with the severity of OSA, implying that left hypothalamic inflammation may
and reproduction in any medium, represent a potential mechanism underlying OSA in obese young patients with
provided the original work is depressive disorders.
properly cited.
Publisher’s Note: AccScience
Publishing remains neutral with Keywords: Obesity; Hypothalamus inflammation; Depressive disorders; Obstructive
regard to jurisdictional claims in sleep apnea
published maps and institutional
affiliations.

Volume 2 Issue 1 (2024) 1 https://doi.org/10.36922/jcbp.1040