Page 90 - JCBP-2-1

Journal of Clinical and
Basic Psychosomatics Psychological high-risk factors for acne

Table 2. Relationship between mood and sleep quality and demonstrating that combined psychological intervention
the occurrence of acne can enhance the treatment effectiveness in papulopustular
rosacea .
[14]
Variables B 96% CI P‑value
Depression According to studies, depressed individuals with
No depression Reference poor sleep quality have high levels of substance P [4-5] .
Substance P promotes the expression of pro-inflammatory
Have depression 0.483 0.288 – 0.678 0.000 cytokines such as IL-1, IL-6, tumor necrosis factor α, and
Anxiety interferon-γ by monocytes, keratinocytes, and mast cells
No anxiety Reference and enhances IL-8 production by neutrophils and skin
Have anxiety −0.132 −0.439 – 0.176 0.401 vascular endothelial cells. These processes influence and
Sleep quality regulate immune and inflammatory responses in the skin,
Good Reference leading to follicular sebaceous gland hyperkeratosis in the
[2-3]
Moderate 0.333 0.118 – 0.548 0.002 funnel ducts and the formation of acne . At the same
time, studies have demonstrated that acne patients have
Poor 0.468 −0.022 – 0.958 0.061 a higher plasma level of levels of substance P compared
Abbreviation: CI: Confidence interval. to individuals without acne. Substance P can stimulate
the hypothalamic-pituitary-adrenal system, promoting
Table 3. Relationship between mood and sleep quality and adrenocortical hormone secretion. This, in turn, reduces
the occurrence of inflammatory acne the patient’s stimulation threshold for stress, resulting in
Variables B 96% CI P‑value changes in endocrine hormones and neurotransmitters in
Depression the body. Ultimately, these factors affect mental health and
.
contribute to forming a vicious circle
[15,16]
No depression Ref
Have depression 0.404 0.178 – 0.629 0.000 In our study, we did not find a significant relationship
Anxiety between anxiety and the occurrence of acne. This lack
of association may be attributed to the fact that our
No anxiety Ref participant sample consisted of students. In the future
Have anxiety −0.243 −0.558 – 0.071 0.129 research, we plan to expand the sample size to further
Sleep quality investigate and explore the relationship between anxiety
Good Ref and the occurrence of acne.
Moderate 0.320 0.106 – 0.535 0.003 5. Conclusion
Poor 0.643 0.051 – 1.235 0.033
Abbreviation: CI: Confidence interval. Our study indicates that within the same individual, the
presence of acne is more likely when their psychological
indicators CRP and interleukin-6 (IL-6). They found that well-being is low (e.g., with depression and decreased
inflammatory indicators were higher in people with high sleep quality). Furthermore, the occurrence rate increases
job stress and low social support (high psychosocial stress) as the decline in psychological well-being worsens. The
at work, suggesting that lower psychological levels promote decrease in psychological well-being can lead to changes in
inflammation and greater susceptibility to acne . These neurotransmitters and endocrine hormones that promote
[12]
findings align with our research, indicating a significant inflammation and exacerbate acne. In turn, acne can
association between depression and the occurrence of acne. diminish the patient’s psychological well-being, resulting in
a vicious cycle. Therefore, in clinical practice, it is crucial
Our findings align with previous literature, supporting to pay attention to the psychological aspects of acne
a link between psychology and skin diseases, particularly patients, particularly depression and sleep quality. Prompt
acne. Arck et al. found that ingesting a lactobacillus intervention is necessary to prevent entering a vicious cycle.
strain in mice inhibited stress-induced neurogenic skin
inflammation, supporting the role of the brain-gut-skin Acknowledgments
axis and significant psychological influence . Wang et al.
[13]
introduced psychological intervention for papulopustular We would like to thank all the individuals that have
rosacea. After 8 weeks of treatment, both groups showed supported this research.
significantly reduced erythema, papulopustular, and Funding
pruritus symptom scores. The intervention group showed
a greater improvement in symptoms than the controls, None.

Volume 2 Issue 1 (2024) 4 https://doi.org/10.36922/jcbp.0944