Page 27 - JCTR-11-1

Journal of Clinical and
Translational Research Pesticides and ischemic heart disease

Table 3. Association between risk of ischemic heart diseases with pesticide exposures
Pesticide use Male Female
IHD (n=441) No IHD (n=4162) P‑value IHD (n=421) No IHD (n=4860) P‑value
Use in farm - n (%) 0.032 0.318
Yes 149 (33.79) 1624 (39.01) 10 (2.38) 83 (1.71)
No 292 (66.21) 2539 (60.99) 411 (97.62) 4777 (98.29)
Duration of exposure in year (minutes) – n (%) 0.020 0.420
No 297 (66.59) 2554 (61.13) 414 (97.64) 4804 (98.32)
≤Mean 124 (27.80) 1249 (29.89) 10 (2.36) 78 (1.60)
>Mean 25 (5.61) 375 (8.98) 0 (0) 4 (0.08)
Use in yard - n (%) 0.905 0.822
Yes 64 (14.51) 613 (14.72) 20 (4.75) 243 (5.00)
No 377 (85.49) 3550 (85.28) 401 (95.25) 4618 (95.00)
Duration of exposure in year (minutes) - n (%) 0.509
No 382 (85.65) 3566 (85.35) 404 (95.28) 4643 (95.03)
≤Mean 45 (10.09) 470 (11.25) 15 (3.54) 199 (4.07)
>Mean 19 (4.26) 142 (3.40) 5 (1.18) 44 (0.90)
Use at home- n (%) 0.063 0.385
Yes 270 (61.22) 2733 (65.67) 351 (83.37) 3970 (81.67)
No 171 (38.78) 1429 (34.33) 70 (16.63) 891 (18.33)
Duration of exposure in year (minutes) - n (%) 0.047 0.397
No 176 (39.46) 1448 (34.66) 73 (17.22) 917 (18.77)
≤Mean 215 (48.21) 2270 (54.33) 274 (64.62) 3195 (65.39)
>Mean 55 (12.33) 460 (11.01) 77 (18.16) 774 (15.84)
Pesticide Preparation - n (%) 0.014 0.143
Yes 112 (25.40) 1292 (31.04) 10 (2.38) 71 (1.46)
No 329 (74.60) 2870 (68.96) 411 (97.62) 4790 (98.54)
Duration of exposure in year (minutes) - n (%) 0.039
No 334 (74.89) 2887 (69.10) 414 (97.64) 4815 (98.55)
≤Mean 93 (20.85) 1055 (25.25) 9 (2.12) 69 (1.41)
>Mean 19 (4.26) 236 (5.65) 1 (0.24) 2 (0.04)
Manage pesticide spraying - n (%) 26.08
Yes 115 (26.08) 903 (21.69) 22 (5.23) 265 (5.45)
No 326 (73.92) 3260 (78.31) 399 (94.77) 4596 (94.55)
Duration of exposure in year (minutes) - n (%) 0.130
No 331 (74.22) 3275 (78.39) 402 (94.81) 4621 (94.58)
≤Mean 85 (19.06) 666 (15.94) 22 (5.19) 252 (5.16)
>Mean 30 (6.73) 237 (5.67) 0 (0) 13 (0.27)
Abbreviation: IHD: Ischemic heart diseases.

London et al., in 1998, showed that the risk of CVD pesticides than in non-farm workers. The study highlighted
25
was higher in the fruit production region than in other safe that some pesticides, such as chlorpyrifos, coumaphos, and
regions, suggesting that agricultural pesticide exposure carbofuran, are acetylcholinesterase inhibitors. 26
could possibly be responsible for the high levels of IHD In an experimental study, Allon et al. exposed rats to a
27
and mortality. Similarly, another study found that the rate pesticide that functions as an acetylcholinesterase inhibitor
of CVDs was higher in farm workers exposed to agriculture and assessed its effects on arrhythmias and mortality rates.

Volume 11 Issue 1 (2025) 21 doi: 10.36922/jctr.22.00187