Page 28 - JCTR-11-2
P. 28
Journal of Clinical and
Translational Research US-mediated drug delivery
treatment. Drug Des Devel Ther. 2013;7:375-388. opening induced by focused ultrasound is dictated
by the acoustic pressure. J Cereb Blood Flow Metab.
doi: 10.2147/DDDT.S31564
2014;34(7):1197-1204.
29. Tung YS, Vlachos F, Choi JJ, Deffieux T, Selert K, doi: 10.1038/jcbfm.2014.71
Konofagou EE. In vivo transcranial cavitation threshold
detection during ultrasound-induced blood-brain barrier 40. Schutt EG, Klein DH, Mattrey RM, Riess JG. Injectable
opening in mice. Phys Med Biol. 2010;55(20):6141-6155. microbubbles as contrast agents for diagnostic ultrasound
imaging: The key role of perfluorochemicals. Angew Chem
doi: 10.1088/0031-9155/55/20/007
Int Ed Engl. 2003;42(28):3218-3235.
30. Bettinger T, Tranquart F. Design of microbubbles for gene/ doi: 10.1002/anie.200200550
drug delivery. Adv Exp Med Biol. 2016;880:191-204.
41. Klibanov AL. Microbubble contrast agents: Targeted
doi: 10.1007/978-3-319-22536-4_11
ultrasound imaging and ultrasound-assisted drug-delivery
31. Becher H, Lofiego C, Mitchell A, Timperley J. Current applications. Invest Radiol. 2006;41(3):354-362.
indications for contrast echocardiography imaging. Eur J doi: 10.1097/01.rli.0000199292.88189.0f
Echocardiogr. 2005;6(Suppl 2):S1-S5.
42. Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ.
doi: 10.1016/s1525-2167(05)80722-x Nano-emulsions. Curr Opin Colloid Interface Sci.
32. Klibanov AL. Ultrasound molecular imaging with 2005;10(3):102-110.
targeted microbubble contrast agents. J Nucl Cardiol. doi: 10.1016/j.cocis.2005.06.004
2007;14(6):876-884.
43. Rapoport N, Nam KH, Gupta R, et al. Ultrasound-mediated
doi: 10.1016/j.nuclcard.2007.09.008 tumor imaging and nanotherapy using drug loaded, block
33. McMahon D, O’Reilly MA, Hynynen K. Therapeutic agent copolymer stabilized perfluorocarbon nanoemulsions.
delivery across the blood-brain barrier using focused J Control Release. 2011;153(1):4-15.
ultrasound. Annu Rev Biomed Eng. 2021;23:89-113. doi: 10.1016/j.jconrel.2011.01.022
doi: 10.1146/annurev-bioeng-062117-121238 44. Apfel RE. Activatable Infusable Dispersions Containing Drops
34. Yang FY, Fu WM, Yang RS, Liou HC, Kang KH, Lin WL. of Superheated Liquid for Methods of Therapy and Diagnosis.
Quantitative evaluation of focused ultrasound with a Patent Number: 5,840,276; 1998
contrast agent on blood-brain barrier disruption. Ultrasound 45. Kripfgans OD, Fowlkes JB, Miller DL, Eldevik OP, Carson PL.
Med Biol. 2007;33(9):1421-1427. Acoustic droplet vaporization for therapeutic and diagnostic
doi: 10.1016/j.ultrasmedbio.2007.04.006 applications. Ultrasound Med Biol. 2000;26(7):1177-1189.
35. McDannold N, Vykhodtseva N, Hynynen K. Effects of doi: 10.1016/s0301-5629(00)00262-3
acoustic parameters and ultrasound contrast agent dose on 46. Vlatakis S, Zhang W, Thomas S, et al. Effect of phase-
focused-ultrasound induced blood-brain barrier disruption. change nanodroplets and ultrasound on blood-brain barrier
Ultrasound Med Biol. 2008;34(6):930-937. permeability in vitro. Pharmaceutics. 2023;16(1):51.
doi: 10.1016/j.ultrasmedbio.2007.11.009 doi: 10.3390/pharmaceutics16010051
36. van Rooy I, Mastrobattista E, Storm G, Hennink WE, 47. Wasielewska JM, White AR. Focused ultrasound-mediated
Schiffelers RM. Comparison of five different targeting drug delivery in humans - a path towards translation in
ligands to enhance accumulation of liposomes into the neurodegenerative diseases. Pharm Res. 2022;39(3):427-439.
brain. J Control Release. 2011;150(1):30-36.
doi: 10.1007/s11095-022-03185-2
doi: 10.1016/j.jconrel.2010.11.014
48. Song R, Zhang C, Teng F, et al. Cavitation-facilitated
37. Kucharz K, Kristensen K, Johnsen KB, et al. Post-capillary transmembrane permeability enhancement induced by
venules are the key locus for transcytosis-mediated brain acoustically vaporized nanodroplets. Ultrason Sonochem.
delivery of therapeutic nanoparticles. Nat Commun. 2021;79:105790.
2021;12(1):4121.
doi: 10.1016/j.ultsonch.2021.105790
doi: 10.1038/s41467-021-24323-1
49. Husseini GA, Diaz de la Rosa MA, Richardson ES,
38. Shpak O, Verweij M, de Jong N, Versluis M. Droplets, Christensen DA, Pitt WG. The role of cavitation in
Bubbles and ultrasound interactions. Adv Exp Med Biol. acoustically activated drug delivery. J Control Release.
2016;880:157-174. 2005;107(2):253-261.
doi: 10.1007/978-3-319-22536-4_9 doi: 10.1016/j.jconrel.2005.06.015
39. Chen H, Konofagou EE. The size of blood-brain barrier 50. Meijering BDM, Juffermans LJM, van Wamel A, et al.
Volume 11 Issue 2 (2025) 22 doi: 10.36922/jctr.24.00061

