Page 100 - JCTR-11-4

Journal of Clinical and
Translational Research NADPH oxidase inhibition in a rodent stroke model

molecular source of ROS in hippocampal neuronal death in 97. Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M,
vascular dementia. Antioxid Redox Signal. 2014;21(4):533-550. STAIR VI Consortium. Stroke Therapy Academic Industry
Roundtable (STAIR) recommendations for extended window
doi: 10.1089/ars.2012.5129
acute stroke therapy trials. Stroke. 2009;40(7):2594-2600.
87. Kim HA, Miller AA, Drummond GR, et al. Vascular doi: 10.1161/STROKEAHA.109.552554
cognitive impairment and Alzheimer’s disease: Role of
cerebral hypoperfusion and oxidative stress. Naunyn 98. Banks WA. From blood-brain barrier to blood-brain
Schmiedebergs Arch Pharmacol. 2012;385(10):953-959. interface: New opportunities for CNS drug delivery. Nat Rev
Drug Discov. 2016;15(4):275-292.
doi: 10.1007/s00210-012-0790-7
doi: 10.1038/nrd.2015.21
88. Bayraktutan U. Nitric oxide synthase and NAD(P)H oxidase
modulate coronary endothelial cell growth. J Mol Cell 99. Hone EA, Hu H, Sprowls SA, et al. Biphasic blood-brain
Cardiol. 2004;36(2):277-286. barrier openings after stroke. Neurol Disord Stroke Int.
2018;1(2):1011.
doi: 10.1016/j.yjmcc.2003.11.005
100. Huang ZG, Xue D, Preston E, Karbalai H, Buchan AM.
89. Bayraktutan U. Coronary microvascular endothelial cell Biphasic opening of the blood-brain barrier following
growth regulates expression of the gene encoding p22-phox. transient focal ischaemia: Effects of hypothermia. Can J
Free Radic Biol Med. 2005;39(10):1342-1352. Neurol Sci. 1999;26(4):298-304.
doi: 10.1016/j.freeradbiomed.2005.06.016 doi: 10.1017/s0317167100000421
90. Knapp LT, Klann E. Role of reactive oxygen species in 101. Rizk NN, Rafols J, Dunbar JC. Cerebral ischaemia induced
hippocampal long-term potentiation: Contributory or apoptosis and necrosis in normal and diabetic rats. Brain
inhibitory? J Neurosci Res. 2002;70(1):1-7. Res. 2005;1053(1-2):1-9.
doi: 10.1002/jnr.10371 doi: 10.1016/j.brainres.2005.05.036
91. Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ. 102. Barth TM, Jones TA, Schallert T. Functional subdivisions
Nox2 redox signalling maintains essential cell populations of the rat somatic sensorimotor cortex. Behav Brain Res.
in the brain. Nat Chem Biol. 2011;7(2):106-112. 1990;39(1):73-95.
doi: 10.1038/nchembio.497 doi: 10.1016/0166-4328(90)90122-u
92. Lau LH, Lew J, Borschmann K, Thijs V, Ekinci EI. 103. Shah FA, Li T, Kury LTA, et al. Pathological comparisons
Prevalence of diabetes and its effects on stroke outcomes: of the hippocampal changes in the transient and permanent
A meta-analysis and literature review. J Diabetes Investig. middle cerebral artery occlusion rat models. Front Neurol.
2019;10(3):780-792. 2019;10:1178.
doi: 10.1111/jdi.12932 doi: 10.3389/fneur.2019.01178
93. Zhang H, Yue K, Jiang Z, et al. Incidence of stress-induced 104. Zhu CZ, Auer RN. Graded hypotension and MCA occlusion
hyperglycaemia in acute ischaemic stroke: A systematic duration: Effect in transient focal ischaemia. J Cereb Blood
review and meta-analysis. Brain Sci. 2023;13(4):556. Flow Metab. 1995;15(6):980-988.
doi: 10.3390/brainsci13040556 doi: 10.1038/jcbfm.1995.124
94. Kiers L, Davis SM, Larkins R, et al. Stroke topography 105. Ming GL, Song H. Adult neurogenesis in the mammalian
and outcome in relation to hyperglycaemia and diabetes. brain: Significant answers and significant questions. Neuron.
J Neurol Neurosurg Psychiatry. 1992;55(4):263-270. 2011;70(4):687-702.
doi: 10.1136/jnnp.55.4.263 doi: 10.1016/j.neuron.2011.05.001
95. Shao B, Bayraktutan U. Hyperglycaemia promotes human 106. Eriksson PS, Perfilieva E, Björk-Eriksson T, et al.
brain microvascular endothelial cell apoptosis via induction Neurogenesis in the adult human hippocampus. Nat Med.
of protein kinase C-ssI and prooxidant enzyme NADPH 1998;4(11):1313-1317.
oxidase. Redox Biol. 2014;2:694-701. doi: 10.1038/3305
doi: 10.1016/j.redox.2014.05.005 107. Wahl F, Allix M, Plotkine M, Boulu RG. Neurological and
96. Kadir RRA, Alwjwaj M, McCarthy Z, Bayraktutan U. behavioural outcomes of focal cerebral ischaemia in rats.
Therapeutic hypothermia augments the restorative effects of Stroke. 1992;23(2):267-272.
PKC-beta and Nox2 inhibition on an in vitro model of human doi: 10.1161/01.str.23.2.267
blood-brain barrier. Metab Brain Dis. 2021;36(7):1817-1832.
108. Okada M, Tamura A, Urae A, et al. Long-term spatial
doi: 10.1007/s11011-021-00810-8 cognitive impairment following middle cerebral artery

Volume 11 Issue 4 (2025) 94 doi: 10.36922/jctr.25.00018