Page 81 - JCTR-11-5

Journal of Clinical and
Translational Research Fibromyalgia: Examination across life domains

Paulo, which may serve as a model for similar initiatives Conflict of interest
in other regions. 54
The authors declare they have no competing interests.
In clinical practice, the current results highlight the
importance of establishing realistic expectations about Author contributions
disease progression and implementing measures to Conceptualization: All authors
slow functional decline. Preventive approaches should Formal analysis: All authors
particularly target domains that showed the largest effect Investigation: All authors
sizes in this study, namely quality of life and self-care, by Methodology: All authors
integrating both psychological and physical treatment Writing–original draft: All authors
protocols. 41
Writing–review & editing: All authors
Finally, several methodological limitations should be
considered when interpreting these findings. First, the Ethics approval and consent to participate
absence of a control group limits causal inferences about the This study was approved by the Western Paraná State
natural progression of functional decline versus potential University Research Ethics Committee, under opinion
intervention effects or other confounding factors. Second, number: 73259023.6.0000.0107. Written informed consent
reliance on participants’ self-reported diagnoses may was obtained from all participants prior to their inclusion
introduce bias. Third, the study sample was predominantly in the study.
female, which, although consistent with the epidemiology
of fibromyalgia, may limit the generalizability of findings Consent for publication
to more diverse populations. Finally, the reliance on self-
reported measures without complementary objective Participants provided their written consent for publication.
functional assessments represents an additional limitation. Availability of data
Future research employing controlled, longitudinal designs
would provide stronger evidence for disease progression Data are available from the corresponding author upon
patterns in chronic pain conditions. reasonable request.
4. Conclusion References

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of decline across domains suggests a systemic rather than 3. Sociedade Brasileira de Reumatologia. Fibromialgia: O
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doi: 10.1016/j.rbre.2017.07.002
Acknowledgments 5. De-Assis M, Paiva E, Helfenstein M, et al. Treatment data

None. from the Brazilian fibromyalgia registry (EpiFibro). Adv
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Funding doi: 10.1186/s42358-019-0108-2

This study was funded by the Araucaria Foundation 6. Clauw DJ. Fibromyalgia: A clinical review. JAMA.
(productivity grant number: 140/2025). 2014;311(15):1547-1555.

Volume 11 Issue 5 (2025) 75 doi: 10.36922/JCTR025290042