Page 15 - JCTR-9-5

Journal of Clinical and Translational Research 2023; 9(5): 317-321

Journal of Clinical and Translational Research

Journal homepage: http://www.jctres.com/en/home

ORIGINAL ARTICLE

Comparison of bronchodilator response between Dosivent and
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Aerochamber Plus Flow-Vu chambers in patients with bronchial
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hyperreactivity

Zichen Ji , Ángela Gómez-Sacristán , Walther Iván Girón-Matute *, Raquel Terán-Marcos , Luis Puente-Maestu 1,2,3
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1 Department of Respiratory, Gregorio Marañón General University Hospital, 28007 Madrid, Spain, Gregorio Marañón Hospital Biomedical
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Investigation Institute, 28007 Madrid, Spain, Department of Medicine, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
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ARTICLE INFO ABSTRACT
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Article history: Background: Aerochambers are used for the administration of inhaled drugs. Dosivent is a
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Received: June 23, 2023 previously unstudied chamber. This study aimed to validate the Dosivent chamber against the widely
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Revised: August 21, 2023 used Aerochamber Plus Flow-Vu .
Accepted: August 21, 2023 Methods: We conducted a non-randomized, open-label, cross-over-controlled, and clinical trial
Published online: September 27, 2023 (NCT05821868) in 50 patients with a known positive bronchodilator test. Bronchodilator washout
was performed according to standard recommendations. Fifteen minutes after the administration
Keywords: of 400 µg of salbutamol with either chamber, the changes in forced expiratory volume in the first
Spirometry second (FEV1) and forced vital capacity (FVC) were measured. The agreement was measured by the
Inhaled therapy intraclass correlation coefficient and Bland–Altman graphical analysis. Participants’ satisfaction with
Aerochamber the chamber was assessed with the FSI-10 questionnaire.
Results: The mean participant age was 58.0 (SD = 18.5) years, half were women, and only 31 (62%)
*Corresponding authors participants had an FEV1/FVC of <0.7. The median increases in FEV1 obtained with the Aerochamber
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Walther Iván Girón-Matute Plus Flow-Vu and Dosivent were 0.28 L (interquartile range [IQR]: 0.21 – 0.38) and 0.29 L (IQR:
Department of Respiratory, Gregorio Marañón 0.20 – 0.43), respectively, and the median increases in FVC were 0.29 L (IQR: 0.19 – 0.37) and 0.28 L
General University Hospital, (IQR: 0.19 – 0.45). The intraclass correlation coefficient for increases in FEV1 was 0.865, and it
28007 Madrid, Spain. was 0.820 for increases in FVC. The median FSI-10 questionnaire score was 42 (IQR: 37 – 47) with
Tel.: +34 91 586 83 36 Aerochamber Plus Flow-Vu and 44 (39 – 48) with Dosivent (P < 0.001).
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E-mail: walter_giron2@hotmail.com Conclusions: Our study revealed a strong agreement between salbutamol responses when utilizing
both the Dosivent and Aerochamber Plus Flow-Vu chambers. This suggests that these devices are
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© 2023 Author(s). This is an Open-Access interchangeable and can be effectively employed in routine clinical practice.
article distributed under the terms of the Relevance for Patients: For patients using inhaled medications, this study provides reassurance
Creative Commons Attribution-Noncommercial ® ®
License, permitting all non-commercial use, regarding the equivalence of the Dosivent chamber with the widely used Aerochamber Plus Flow-
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distribution, and reproduction in any medium, Vu . This provides patients with more options for device selection, potentially improving convenience
provided the original work is properly cited. and satisfaction with their inhalation therapy. Patients and healthcare providers can consider the
Dosivent chamber as a viable alternative, which may positively impact treatment adherence and
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overall respiratory health management.
1. Introduction
Inhaled therapy is an airway administration route for bronchodilator and anti-inflammatory
drugs that are widely used in patients with obstructive respiratory conditions such as asthma
and chronic obstructive pulmonary disease (COPD) [1,2]. It is also often used in pulmonary
function laboratories for bronchodilator tests [3,4]. This method of administration allows a

DOI: http://dx.doi.org/10.18053/jctres.09.202305.23-00081