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Sempere-Rubio et al. | Journal of Clinical and Translational Research 2023; 9(6): 369-380 377
of included studies, the conclusions are somewhat ambiguous 2001;5:320-9.
as they satisfy a qualitative analysis, and not a quantitative one [6] Treister-Goltzman Y, Peleg R. Fibromyalgia and Mortality:
(which would be more robust). A Systematic Review and Meta-analysis. RMD Open
5. Conclusion 2023;9:e003005.
[7] Dadabhoy D, Crofford LJ, Spaeth M, Russell IJ, Clauw DJ.
Overall, it seems that the addition of HEI to other interventions Biology and Therapy of Fibromyalgia. Evidence-based
leads to greater clinical improvements than HEI in isolation. We Biomarkers for Fibromyalgia Syndrome. Arthritis Res
have seen this especially in some clinical variables of interest such Ther 2008;10:211.
as pain intensity or quality of life. It seems that the main strength [8] Kumbhare D, Ahmed S, Watter S. A Narrative Review on
of the HEI is the interaction with other interventions to enhance its the Difficulties Associated with Fibromyalgia Diagnosis.
efficacy with respect to the outcomes assessed. Further research Ther Adv Musculoskelet Dis 2018;10:13-26.
is needed especially ensuring the correct comparison when [9] Kang JH, Choi SE, Park DJ, Lee SS. Disentangling
combining HEI with other interventions to obtain more consistent Diagnosis and Management of Fibromyalgia. J Rheum Dis
results. 2022;29:4-13.
Finally, we could raise public awareness through informative
campaigns, and on the health-care front, we can implement [10] Garcia-Campayo J, Magdalena J, Magallón R, Fernández-
educational programs for health-care professionals with the aim García E, Salas M, Andrés E. A Meta-analysis of the
of improving the understanding and management of FMS. Efficacy of Fibromyalgia Treatment According to Level of
Care. Arthritis Res Ther 2008;10:R81.
Acknowledgments [11] Migliorini F, Maffulli N, Knobe M, Tenze G, Aljalloud A,

None. Colarossi G. Pregabalin Administration in Patients with
Fibromyalgia: A Bayesian Network Meta-analysis. Sci
Funding Rep 2022;12:12148.
[12] Bernardy K, Klose P, Welsch P, Häuser W. Efficacy,
None.
Acceptability and Safety of Cognitive Behavioural
Conflicts of Interest Therapies in Fibromyalgia Syndrome - A Systematic
Review and Meta-analysis of Randomized Controlled
None declared. Trials. Eur J Pain 2018;22:242-60.

Ethics Approval and Consent to Participate [13] Bernardy K, Füber N, Köllner V, Häuser W. Efficacy
of Cognitive-behavioral Therapies in Fibromyalgia
Not applicable. Syndrome - a Systematic Review and Metaanalysis

Consent for Publication of Randomized Controlled Trials. J Rheumatol
2010;37:1991-2005.
Not applicable. [14] Häuser W, Klose P, Langhorst J, Moradi B, Steinbach M,
Schiltenwolf M, et al. Efficacy of different Types of Aerobic
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