Page 107 - MI-2-1

Microbes & Immunity Advax-adjuvanted typhoid vaccine

nonhuman primates. Vaccine. 2022;40:4625-4634. JE‑ADVAX vaccine protection against Japanese encephalitis
virus mediated by memory B cells in the absence of CD8(+)
doi: 10.1016/j.vaccine.2022.06.043
T cells and pre-exposure neutralizing antibody. J Virol.
25. Cartee RT, Thanawastien A, Griffin Iv TJ, Mekalanos JJ, Bart S, 2013;87:4395-4402.
Killeen KP. A phase 1 randomized safety, reactogenicity, and doi: 10.1128/JVI.03144‑12
immunogenicity study of Typhax: A novel protein capsular
matrix vaccine candidate for the prevention of typhoid fever. 35. Li L, Honda‑Okubo Y, Li C, Sajkov D, Petrovsky N. Delta
PLoS Negl Trop Dis. 2020;14:e0007912. inulin adjuvant enhances plasmablast generation, expression
of activation-induced cytidine deaminase and B-cell affinity
doi: 10.1371/journal.pntd.0007912
maturation in human subjects receiving seasonal influenza
26. Katkocin DM. Characterization of multivalent pneumococcal vaccine. PLoS One. 2015;10:e0132003.
conjugate vaccines. Dev Biol (Basel). 2000;103:113-119.
doi: 10.1371/journal.pone.0132003
27. Singleton KL, Joffe A, Leitner WW. Review: Current trends, 36. Petrovsky N, Larena M, Siddharthan V, et al. An inactivated
challenges, and success stories in adjuvant research. Front cell culture Japanese encephalitis vaccine (JE‑ADVAX)
Immunol. 2023;14:1105655. formulated with delta inulin adjuvant provides robust
doi: 10.3389/fimmu.2023.1105655 heterologous protection against West Nile encephalitis via
cross-protective memory B cells and neutralizing antibody.
28. Cooper PD, Barclay TG, Ginic‑Markovic M, Petrovsky N. J Virol. 2013;87:10324-10333.
The polysaccharide inulin is characterized by an extensive
series of periodic isoforms with varying biological actions. doi: 10.1128/JVI.00480‑13
Glycobiology. 2013;23:1164-1174. 37. Davtyan H, Zagorski K, Rajapaksha H, et al. Alzheimer’s
doi: 10.1093/glycob/cwt053 disease Advax(CpG)‑adjuvanted MultiTEP‑based dual
and single vaccines induce high-titer antibodies against
29. Cooper PD, Petrovsky N. Delta inulin: A novel, various forms of tau and Abeta pathological molecules. Sci
immunologically active, stable packing structure comprising Rep. 2016;6:28912.
beta‑D‑[2 ‑> 1] poly(fructo-furanosyl) alpha-D-glucose
polymers. Glycobiology. 2011;21:595-606. doi: 10.1038/srep28912
doi: 10.1093/glycob/cwq201 38. Gordon D, Kelley P, Heinzel S, Cooper P, Petrovsky N.
Immunogenicity and safety of Advax, a novel polysaccharide
30. Petrovsky N, Cooper PD. Advax, a novel microcrystalline adjuvant based on delta inulin, when formulated with
polysaccharide particle engineered from delta inulin, hepatitis B surface antigen: A randomized controlled Phase
provides robust adjuvant potency together with tolerability 1 study. Vaccine. 2014;32:6469-6477.
and safety. Vaccine. 2015;33:5920-5926.
doi: 10.1016/j.vaccine.2014.09.034
doi: 10.1016/j.vaccine.2015.09.030
39. Gordon DL, Sajkov D, Honda‑Okubo Y, et al. Human Phase
31. Counoupas C, Pinto R, Nagalingam G, Britton WJ, 1 trial of low-dose inactivated seasonal influenza vaccine
Petrovsky N, Triccas JA. Delta inulin‑based adjuvants formulated with Advax delta inulin adjuvant. Vaccine.
promote the generation of polyfunctional CD4(+) T cell 2016;34:3780-3786.
responses and protection against Mycobacterium tuberculosis
infection. Sci Rep. 2017;7:8582. doi: 10.1016/j.vaccine.2016.05.071
doi: 10.1038/s41598-017-09119-y 40. Heddle R, Smith A, Woodman R, Hissaria P, Petrovsky N.
Randomized controlled trial demonstrating the benefits of
32. Honda‑Okubo Y, Barnard D, Ong CH, Peng BH, Tseng CT, delta inulin adjuvanted immunotherapy in patients with bee
Petrovsky N. Severe acute respiratory syndrome‑associated venom allergy. J Allergy Clin Immunol. 2019;144:504-513.
coronavirus vaccines formulated with delta inulin adjuvants e16.
provide enhanced protection while ameliorating lung
eosinophilic immunopathology. J Virol. 2015;89:2995-3007. doi: 10.1016/j.jaci.2019.03.035
41. Li L, Honda‑Okubo Y, Baldwin J, Bowen R, Bielefeldt‑
doi: 10.1128/JVI.02980‑14
Ohmann H, Petrovsky N. Covax‑19/Spikogen(R) vaccine
33. Honda‑Okubo Y, Saade F, Petrovsky N. Advax, a based on recombinant spike protein extracellular domain
polysaccharide adjuvant derived from delta inulin, provides with Advax‑CpG55.2 adjuvant provides single dose
improved influenza vaccine protection through broad- protection against SARS‑CoV‑2 infection in hamsters.
based enhancement of adaptive immune responses. Vaccine. Vaccine. 2022;40:3182-3192.
2012;30:5373-5381.
doi: 10.1016/j.vaccine.2022.04.041
doi: 10.1016/j.vaccine.2012.06.021
42. Tabarsi P, Anjidani N, Shahpari R, et al. Evaluating the
34. Larena M, Prow NA, Hall RA, Petrovsky N, Lobigs M. efficacy and safety of SpikoGen(R), an Advax‑CpG55.2‑

Volume 2 Issue 1 (2025) 99 doi: 10.36922/mi.4497