Page 21 - MI-2-1

Microbes & Immunity Sepsis and gut microbiome

doi: 10.1016/j.chom.2018.01.005 research. Lancet Infect Dis. 2019;19(12):e422-e436.
37. Desai MS, Seekatz AM, Koropatkin NM, et al. A dietary doi: 10.1016/S1473-3099(19)30567-5
fiber-deprived gut microbiota degrades the colonic 48. O’Boyle CJ, MacFie J, Mitchell CJ, Johnstone D, Sagar PM,
mucus barrier and enhances pathogen susceptibility. Cell.
2016;167(5):1339-1353.e21. Sedman PC. Microbiology of bacterial translocation in
humans. Gut. 1998;42(1):29-35.
doi: 10.1016/j.cell.2016.10.043
doi: 10.1136/gut.42.1.29
38. Kumar M, Leon Coria A, Cornick S, et al. Increased
intestinal permeability exacerbates sepsis through reduced 49. Abo-Shaban T, Sharna SS, Hosie S, et al. Issues for patchy
hepatic SCD-1 activity and dysregulated iron recycling. Nat tissues: Defining roles for gut-associated lymphoid tissue in
Commun. 2020;11(1):483. neurodevelopment and disease. J Neural Transm (Vienna).
2023;130(3):269-280.
doi: 10.1038/s41467-019-14182-2
doi: 10.1007/s00702-022-02561-x
39. Darkwah S, Nago N, Appiah MG, et al. Differential roles
of dendritic cells in expanding CD4 T cells in sepsis. 50. Torow N, Li R, Hitch TCA, et al. M cell maturation and cDC
Biomedicines. 2019;7(3):52. activation determine the onset of adaptive immune priming
in the neonatal Peyer’s patch. Immunity. 2023;56(6):1220-
doi: 10.3390/BIOMEDICINES7030052 1238.e7.
40. Worthington JJ, Reimann F, Gribble FM. Enteroendocrine doi: 10.1016/j.immuni.2023.04.002
cells-sensory sentinels of the intestinal environment and
orchestrators of mucosal immunity. Mucosal Immunol. 51. De Schepper S, Verheijden S, Aguilera-Lizarraga J, et al. Self-
2018;11(1):3-20. maintaining Gut macrophages are essential for intestinal
homeostasis. Cell. 2018;175(2):400-415.e13.
doi: 10.1038/mi.2017.73
doi: 10.1016/j.cell.2018.07.048
41. Camilleri M. Leaky gut: Mechanisms, measurement and
clinical implications in humans. Gut. 2019;68(8):1516-1526. 52. Martínez-López M, Iborra S, Conde-Garrosa R, et al.
Microbiota sensing by mincle-syk axis in dendritic cells
doi: 10.1136/gutjnl-2019-318427 regulates interleukin-17 and -22 production and promotes
42. Horowitz A, Chanez-Paredes SD, Haest X, Turner JR. intestinal barrier integrity. Immunity. 2019;50(2):446-
Paracellular permeability and tight junction regulation 461.e9.
in gut health and disease. Nat Rev Gastroenterol Hepatol. doi: 10.1016/j.immuni.2018.12.020
2023;20(7):417-432.
53. Schulz O, Ugur M, Friedrichsen M, et al. Hypertrophy of
doi: 10.1038/s41575-023-00766-3 infected Peyer’s patches arises from global, interferon-
43. Oami T, Abtahi S, Shimazui T, et al. Claudin-2 upregulation receptor, and CD69-independent shutdown of lymphocyte
enhances intestinal permeability, immune activation, egress. Mucosal Immunol. 2014;7(4):892-904.
dysbiosis, and mortality in sepsis. Proc Natl Acad Sci U S A. doi: 10.1038/mi.2013.105
2024;121(10):e2217877121.
54. Fan J, Wu J, Wu LD, et al. Effect of parenteral glutamine
doi: 10.1073/pnas.2217877121 supplementation combined with enteral nutrition on Hsp90
44. Bemark M, Pitcher MJ, Dionisi C, Spencer J. Gut-associated expression and Peyer’s patch apoptosis in severely burned
lymphoid tissue: A microbiota-driven hub of B cell rats. Nutrition. 2018;47:97-103.
immunity. Trends Immunol. 2024;45(3):211-223. doi: 10.1016/j.nut.2017.10.005
doi: 10.1016/j.it.2024.01.006 55. Ota N, Wong K, Valdez PA, et al. IL-22 bridges the
45. Pearson C, Uhlig HH, Powrie F. Lymphoid lymphotoxin pathway with the maintenance of colonic
microenvironments and innate lymphoid cells in the gut. lymphoid structures during infection with Citrobacter
Trends Immunol. 2012;33(6):289-296. rodentium. Nat Immunol. 2011;12(10):941-948.
doi: 10.1016/j.it.2012.04.004 doi: 10.1038/ni.2089
46. Czepielewski RS, Erlich EC, Onufer EJ, et al. Ileitis- 56. Eberl G, Lochner M. The development of intestinal
associated tertiary lymphoid organs arise at lymphatic valves lymphoid tissues at the interface of self and microbiota.
and impede mesenteric lymph flow in response to tumor Mucosal Immunol. 2009;2(6):478-485.
necrosis factor. Immunity. 2021;54(12):2795-2811.e9. doi: 10.1038/mi.2009.114
doi: 10.1016/j.immuni.2021.10.003
57. Buettner M, Lochner M. Development and function of
47. Rubio I, Osuchowski MF, Shankar-Hari M, et al. Current gaps secondary and tertiary lymphoid organs in the small
in sepsis immunology: New opportunities for translational intestine and the colon. Front Immunol. 2016;7:342.

Volume 2 Issue 1 (2025) 13 doi: 10.36922/mi.4742