Page 22 - MI-2-1
P. 22
Microbes & Immunity Sepsis and gut microbiome
doi: 10.3389/fimmu.2016.00342 doi: 10.1038/s41575-019-0173-3
58. Wu C, Li H, Zhang P, et al. Lymphatic flow: A potential target 69. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus
in sepsis-associated acute lung injury. JIR. 2020;13:961-968. document: The International Scientific Association for
doi: 10.2147/JIR.S284090 Probiotics and Prebiotics (ISAPP) consensus statement on
the definition and scope of prebiotics. Nat Rev Gastroenterol
59. Hotchkiss RS, Tinsley KW, Swanson PE, et al. Sepsis- Hepatol. 2017;14(8):491-502.
induced apoptosis causes progressive profound depletion
of B and CD4+ T lymphocytes in humans. J Immunol. doi: 10.1038/nrgastro.2017.75
2001;166(11):6952-6963. 70. Valcheva R, Koleva P, Martínez I, Walter J, Gänzle MG,
doi: 10.4049/jimmunol.166.11.6952 Dieleman LA. Inulin-type fructans improve active ulcerative
colitis associated with microbiota changes and increased short-
60. Peng S, Sun T, Yang D, et al. Dipsacoside B ameliorates chain fatty acids levels. Gut Microbes. 2019;10(3):334-357.
cognitive impairment in sepsis-associated encephalopathy
by reducing Th17 cell infiltration and neuroinflammation. doi: 10.1080/19490976.2018.1526583
Biochem Pharmacol. 2024;227:116428. 71. Wei W, Wong CC, Jia Z, et al. Parabacteroides distasonis
doi: 10.1016/j.bcp.2024.116428 uses dietary inulin to suppress NASH via its metabolite
pentadecanoic acid. Nat Microbiol. 2023;8(8):1534-1548.
61. Xie B, Wang M, Zhang X, et al. Gut-derived memory γδ
T17 cells exacerbate sepsis-induced acute lung injury in doi: 10.1038/s41564-023-01418-7
mice. Nat Commun. 2024;15(1):6737. 72. Dilli D, Aydin B, Fettah ND, et al. The propre-save study:
doi: 10.1038/s41467-024-51209-9 Effects of probiotics and prebiotics alone or combined on
necrotizing enterocolitis in very low birth weight infants.
62. Van Rossum T, Haiß A, Knoll RL, et al. Bifidobacterium
and Lactobacillus probiotics and gut dysbiosis in preterm J Pediatr. 2015;166(3):545-551.e1.
infants: The PRIMAL randomized clinical trial. JAMA doi: 10.1016/j.jpeds.2014.12.004
Pediatr. 2024;178:985-995.
73. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A.
doi: 10.1001/jamapediatrics.2024.2626 Inulin controls inflammation and metabolic endotoxemia in
women with type 2 diabetes mellitus: A randomized-controlled
63. Angurana SK, Bansal A, Singhi S, et al. Evaluation of effect
of probiotics on cytokine levels in critically Ill children with clinical trial. Int J Food Sci Nutr. 2014;65(1):117-123.
severe sepsis: A double-blind, placebo-controlled trial. Crit doi: 10.3109/09637486.2013.836738
Care Med. 2018;46(10):1656-1664.
74. Hecht AL, Harling LC, Friedman ES, et al. Dietary
doi: 10.1097/CCM.0000000000003279 carbohydrates regulate intestinal colonization and
64. Xie S, Li J, Lyu F, et al. Novel tripeptide RKH derived from dissemination of Klebsiella pneumoniae. J Clin Invest.
Akkermansia muciniphila protects against lethal sepsis. Gut. 2024;134(9):e174726.
2023;73:78-91. doi: 10.1172/JCI174726
doi: 10.1136/gutjnl-2023-329996 75. Macia L, Tan J, Vieira AT, et al. Metabolite-sensing receptors
65. Gu P, Liu R, Yang Q, et al. A metabolite from commensal GPR43 and GPR109A facilitate dietary fibre-induced gut
Candida albicans enhances the bactericidal activity of homeostasis through regulation of the inflammasome. Nat
macrophages and protects against sepsis. Cell Mol Immunol. Commun. 2015;6(1):6734.
2023;20(10):1156-1170. doi: 10.1038/ncomms7734
doi: 10.1038/s41423-023-01070-5 76. Pryde SE, Duncan SH, Hold GL, Stewart CS, Flint HJ. The
66. Chen X, Wu R, Li L, et al. Pregnancy-induced changes to the microbiology of butyrate formation in the human colon.
gut microbiota drive macrophage pyroptosis and exacerbate FEMS Microbiol Lett. 2002;217(2):133-139.
septic inflammation. Immunity. 2023;56(2):336-352.e9. doi: 10.1111/j.1574-6968.2002.tb11467.x
doi: 10.1016/j.immuni.2023.01.015 77. Liu S, Hong L, Zhang S, et al. Sporisorium reilianum
67. Quigley EMM. Prebiotics and probiotics in digestive health. polysaccharides improve DSS-induced ulcerative colitis by
Clin Gastroenterol Hepatol. 2019;17(2):333-344. regulating intestinal barrier function and metabolites. Int J
Biol Macromol. 2024;265:130863.
doi: 10.1016/j.cgh.2018.09.028
doi: 10.1016/j.ijbiomac.2024.130863
68. Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA.
Probiotics and prebiotics in intestinal health and disease: 78. Tajik N, Frech M, Schulz O, et al. Targeting zonulin and
From biology to the clinic. Nat Rev Gastroenterol Hepatol. intestinal epithelial barrier function to prevent onset of
2019;16(10):605-616. arthritis. Nat Commun. 2020;11(1):1995.
Volume 2 Issue 1 (2025) 14 doi: 10.36922/mi.4742

