Page 21 - MI-2-4
P. 21
Microbes & Immunity Regulation of Staphylococcus aureus CP biosynthesis
53. Østerlid KE, Sorieul C, Unione L, et al. Long, synthetic production at the transcription level in Staphylococcus
Staphylococcus aureus type 8 capsular oligosaccharides aureus. Microbiology (Reading). 2016;162(3):575-589.
reveal structural epitopes for effective immune recognition. doi: 10.1099/mic.0.000243
J Am Chem Soc. 2025;147(3):2829-2840.
64. Dassy B, Hogan T, Foster TJ, Fournier JM. Involvement of
doi: 10.1021/jacs.4c16118
the accessory gene regulator (agr) in expression of type 5
54. Sorieul C, Mikladal B, Wu DY, et al. Multimeric, multivalent capsular polysaccharide by Staphylococcus aureus. J Gen
fusion carrier proteins for site-selective glycoconjugate Microbiol. 1993;139(6):1301-1306.
vaccines simultaneously targeting Staphylococcus aureus and doi: 10.1099/00221287-139-6-1301
Pseudomonas aeruginosa. Chem Sci. 2025;16(13):5688-5700.
65. George SE, Nguyen T, Geiger T, et al. Phenotypic
doi: 10.1039/d4sc08622h
heterogeneity and temporal expression of the capsular
55. Sau S, Bhasin N, Wann ER, Lee JC, Foster TJ, Lee CY. The polysaccharide in Staphylococcus aureus. Mol Microbiol.
Staphylococcus aureus allelic genetic loci for serotype 5 and 8 2015;98(6):1073-1088.
capsule expression contain the type-specific genes flanked by doi: 10.1111/mmi.13174
common genes. Microbiology (Reading). 1997;143(7):2395-2405.
66. Van Wamel W, Xiong YQ, Bayer AS, Yeaman MR, Nast CC,
doi: 10.1099/00221287-143-7-2395
Cheung AL. Regulation of Staphylococcus aureus type 5
56. Kneidinger B, O’Riordan K, Li J, Brisson JR, Lee JC, Lam JS. capsular polysaccharides by agr and sarA in vitro and
Three highly conserved proteins catalyze the conversion in an experimental endocarditis model. Microb Pathog.
of UDP-N-acetyl-D-glucosamine to precursors for the 2002;33(2):73-79.
biosynthesis of O antigen in Pseudomonas aeruginosa O11 doi: 10.1006/mpat.2002.0513
and capsule in Staphylococcus aureus type 5. Implications
for the UDP-N-acetyl-L-fucosamine biosynthetic pathway. 67. Luong T, Sau S, Gomez M, Lee JC, Lee YC. Regulation of
J Biol Chem. 2003;278(6):3615-3627. Staphylococcus aureus capsular polysaccharide expression
by agr and sarA. Infect Immun. 2002;70(2):444-450.
doi: 10.1074/jbc.M203867200
doi: 10.1128/IAI.70.2.444-450.2002
57. Bhasin N, Albus A, Michon F, Livolsi PJ, Park JS, Lee JC.
Identification of a gene essential for O-acetylation of the 68. Luong TT, Lee CY. The arl locus positively regulates
Staphylococcus aureus type 5 capsular polysaccharide. Mol Staphylococcus aureus type 5 capsule via an mgrA-dependent
Microbiol. 1998;27(1):9-21. pathway. Microbiology (Reading). 2006;152(10):3123-3131.
doi: 10.1046/j.1365-2958.1998.00646.x doi: 10.1099/mic.0.29177-0
58. Herbert S, Newell SW, Lee C, et al. Regulation of Staphylococcus 69. Seidl K, Muller S, Francois P, et al. Effect of a glucose
aureus type 5 and type 8 capsular polysaccharides by CO . impulse on the CcpA regulon in Staphylococcus aureus.
2
J Bacteriol. 2001;183(15):4609-4613. BMC Microbiol. 2009;18(9):95.
doi: 10.1128/JB.183.15.4609–4613.2001 doi: 10.1186/1471-2180-9-95
59. Ouyang S, Sau S, Lee CY. Promoter analysis of the cap8 operon, 70. Zhu Y, Nandakumar R, Sadykov MR, et al. RpiR homologues
involved in type 8 capsular polysaccharide production in may link Staphylococcus aureus RNAIII synthesis and
Staphylococcus aureus. J Bacteriol. 1999;181(8):2492-2500. pentose phosphate pathway regulation. J Bacteriol.
2011;193(22):6187-6196.
doi: 10.1128/JB.181.8.2492-2500.1999
doi: 10.1128/JB.05930-11
60. Jutras BL, Chenail AM, Rowland CL, et al. Eubacterial
SpoVG homologs constitute a new family of site-specific 71. Gaupp R, Wirf J, Wonnenberg B, et al. RpiRc is a pleiotropic
DNA-binding proteins. PLos One. 2013;8(6):e66683. effector of virulence determinant synthesis and attenuates
pathogenicity in Staphylococcus aureus. Infect Immun.
doi: 10.1371/journal.pone.0066683
2016;84(7):2031-2041.
61. Lei MG, Lee CY. RbsR activates capsule but represses the doi: 10.1128/IAI.00285-16
rbsUDK operon in Staphylococcus aureus. J Bacteriol.
2015;197(23):3666-3675. 72. Graham JW, Lei MG, Lee CY. Trapping and identification
of cellular substrates of the Staphylococcus aureus ClpC
doi: 10.1128/JB.00640-15
chaperone. J Bacteriol. 2013;195(19):4506-4516.
62. Lei MG, Lee CY. MgrA activates staphylococcal capsule via doi: 10.1128/JB.00758-13
SigA-dependent promoter. J Bacteriol. 2020;203(2):e00495-20.
73. Romilly C, Lays C, Tomasini A, et al. A non-coding RNA
doi: 10.1128/JB.00495-20
promotes bacterial persistence and decreases virulence by
63. Batte JL, Samanta D, Elasri MO. MsaB activates capsule regulating a regulator in Staphylococcus aureus. PLoS Pathog.
Volume 2 Issue 4 (2025) 13 doi: 10.36922/mi.8392

