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Materials Science in Additive Manufacturing Fibrous silk in biomedicine
mechanical properties in regenerated forms, incomplete References
understanding of long-term biosafety, and challenges in 1. Hench LL, Polak JM. Third-generation biomedical materials.
standardization and large-scale production. Future research Science. 2002;295(5557):1014-1017.
should prioritize the development of multifunctional,
application-specific FS composites, long-term in vivo doi: 10.1126/science.1067404
validation in large animal models, and regulatory pathways 2. Bowles RD, Setton LA. Biomaterials for intervertebral disc
to facilitate clinical translation. With continued innovation regeneration and repair. Biomaterials. 2017;129:54-67.
in biofunctionalization and 3D printing, FS is poised to doi: 10.1016/j.biomaterials.2017.03.013
play a significant role in the next generation of personalized 3. Zhang J, Guo Y, Bai Y, Wei Y. Application of biomedical
and regenerative medical therapies. materials in the diagnosis and treatment of myocardial
Acknowledgments infarction. J Nanobiotechnol. 2023;21(1):298.
doi: 10.1186/s12951-023-02063-2
None.
4. Fan L, Chen S, Yang M, Liu Y, Liu J. Metallic materials for
Funding bone repair. Adv Healthc Mater. 2024;13(3):e2302132.
This study was supported by the National Clinical Medical doi: 10.1002/adhm.202302132
Research Center of Orthopedics and Sports Rehabilitation 5. Saghazadeh S, Rinoldi C, Schot M, et al. Drug delivery
Innovation Fund (2021-NCRC-CXJJPY-17) and the systems and materials for wound healing applications. Adv
Clinical Research Incubation Program of Beijing Chao- Drug Deliv Rev. 2018;127:138-166.
Yang Hospital (CYFH202316). doi: 10.1016/j.addr.2018.04.008
Conflict of interest 6. Balmayor ER, van Griensven M. Drug delivery to bony
tissue. Adv Drug Deliv Rev. 2015;94:1-2.
The authors declare that they have no known competing doi: 10.1016/j.addr.2015.10.018
financial interests or personal relationships that could have
appeared to influence the work reported in this paper. 7. Belbéoch C, Lejeune J, Vroman P, Salaün F. Silkworm and
spider silk electrospinning: A review. Environ Chem Lett.
Author contributions 2021;19(2):1737-1763.
Conceptualization: Yong Hai, Juan Guan, Yuzeng Liu, doi: 10.1007/s10311-020-01147-x
Mingzheng Zhao, Shixuan Guo, Fengqi 8. Huang W, Ling S, Li C, Omenetto FG, Kaplan DL. Silkworm
Cheng, Wenhan Tian silk-based materials and devices generated using bio-
Data curation: Mingzheng Zhao, Shixuan Guo, Fengqi nanotechnology. Chem Soc Rev. 2018;47(17):6486-6504.
Cheng, Wenhan Tian doi: 10.1039/c8cs00187a
Visualization: Fengqi Cheng, Wenhan Tian 9. Li B, Sun Q, Yu X, et al. Molecular mechanisms of silk
Writing – original draft: Mingzheng Zhao, Shixuan Guo gland damage caused by phoxim exposure and protection
Writing – review & editing: Yong Hai, Juan Guan, Yuzeng of phoxim-induced damage by cerium chloride in Bombyx
Liu mori. J Appl Toxicol. 2015;30(9):1102-1111.
All authors approved the final version of the manuscript, doi: 10.1002/tox.21983
contributed to the article, and approved the submitted
version. 10. Numata K, Cebe P, Kaplan DL. Mechanism of enzymatic
degradation of beta-sheet crystals. Biomaterials.
Ethics approval and consent to participate 2010;31(10):2926-2933.
Not applicable. doi: 10.1016/j.biomaterials.2009.12.026
11. Keten S, Xu Z, Ihle B, Buehler MJ. Nanoconfinement
Consent for publication controls stiffness, strength and mechanical toughness of
beta-sheet crystals in silk. Nat Mater. 2010;9(4):359-367.
Not applicable.
doi: 10.1038/nmat2704
Availability of data 12. Moy RL, Lee A, Zalka A. Commonly used suture materials
The original data from this study are publicly available on in skin surgery. Am Fam Physician. 1991;44(6):2123-2128.
Google Scholar and can be accessed using the reference 13. Guo C, Li C, Kaplan DL. Enzymatic degradation of
titles or DOI numbers. Bombyx mori silk materials: A review. Biomacromolecules.
Volume 4 Issue 2 (2025) 18 doi: 10.36922/MSAM025130020

