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Figure 2. A brief history of organoids
Abbreviations: ESC: Embryonic stem cells; PSCs: Pluripotent stem cells; iPSCs: Induced pluripotent stem cells.

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foundation for designing these advanced biomaterials. This to physiological signals in real time. This dynamic control
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interdisciplinary approach guides the development of synthetic allows for the creation of organoids that closely replicate the
biomaterials that dynamically interact with cells, promoting complexity of human tissues. 44
self-organization and tissue-specific differentiation. Bioactive The application of materiobiology in organoid research
materials embedded with growth factors, peptides, and promises to revolutionize the field by enabling precise,
adhesion ligands create a microenvironment conducive to scalable, and ethically sustainable models. As synthetic
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organoid maturation. 37,38 Moreover, bioresponsive materials biomaterials continue to evolve, their integration into
capable of adapting to environmental changes further organoid technology is poised to overcome present
enhance organoid culture. Stimuli-responsive hydrogels limitations and set new standards in biomedical research
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can regulate the release of bioactive molecules, 40-42 adjusting and personalized medicine. 46

Volume 1 Issue 1 (2025) 4 doi: 10.36922/OR025040007