Page 83 - OR-1-1
P. 83
Translational Research in Traumatic Brain Injury. Ch. 5. Boca 74. Petersilie L, Heiduschka S, Nelson JSE, et al. Cortical brain
Raton, FL: CRC Press/Taylor and Francis Group; 2016. organoid slices (cBOS) for the study of human neural cells in
minimal networks. iScience. 2024;27(4):109415.
63. Silvosa MJ, Mercado NR, Merlock N, et al. Understanding
primary blast injury: High frequency pressure acutely doi: 10.1016/j.isci.2024.109415
disrupts neuronal network dynamics in cerebral organoids. 75. Tang J, Zheng H, Feng Y, Zeng J, Ma S. Attachment culture of
J Neurotrauma. 2022;39(21-22):1575-1590.
cortical organoids at the microwell air-liquid interface. STAR
doi: 10.1089/neu.2022.0044 Protoc. 2023;4(3):102502.
64. Morrison B 3 , Cater HL, Benham CD, Sundstrom LE. doi: 10.1016/j.xpro.2023.102502
rd
An in vitro model of traumatic brain injury utilising two-
dimensional stretch of organotypic hippocampal slice 76. Qian X, Su Y, Adam CD, et al. Sliced human cortical
cultures. J Neurosci Methods. 2006;150(2):192-201. organoids for modeling distinct cortical layer formation. Cell
Stem Cell. 2020;26(5):766-781.e9.
doi: 10.1016/j.jneumeth.2005.06.014
doi: 10.1016/j.stem.2020.02.002
65. Ramirez S, Mukherjee A, Sepulveda S, et al. Modeling
traumatic brain injury in human cerebral organoids. Cells. 77. Hutchinson PJ, Kolias AG, Timofeev IS, et al. Trial of
2021;10(10):2683. decompressive craniectomy for traumatic intracranial
hypertension. N Engl J Med. 2016;375(12):1119-1130.
doi: 10.3390/cells10102683
doi: 10.1056/NEJMoa1605215
66. Hamilton KA, Santhakumar V. Current ex vivo and in vitro
approaches to uncovering mechanisms of neurological 78. Chukwurah E, Osmundsen A, Davis SW, Lizarraga SB.
dysfunction after traumatic brain injury. Curr Opin Biomed All together now: Modeling the interaction of neural with
Eng. 2020;14:18-24. non-neural systems using organoid models. Front Neurosci.
2019;13:582.
doi: 10.1016/j.cobme.2020.05.001
doi: 10.3389/fnins.2019.00582
67. Tang-Schomer MD, White JD, Tien LW, et al. Bioengineered
functional brain-like cortical tissue. Proc Natl Acad Sci U S A. 79. Raghupathi R, Graham DI, McIntosh TK. Apoptosis after
2014;111(38):13811-13816. traumatic brain injury. J Neurotrauma. 2000;17(10):927-938.
doi: 10.1073/pnas.1324214111 doi: 10.1089/neu.2000.17.927
68. Chwalek K, Tang-Schomer MD, Omenetto FG, Kaplan DL. 80. Clark RS, Kochanek PM, Watkins SC, et al. Caspase-3
In vitro bioengineered model of cortical brain tissue. Nat mediated neuronal death after traumatic brain injury in rats.
Protoc. 2015;10(9):1362-1373. J Neurochem. 2000;74(2):740-753.
doi: 10.1038/nprot.2015.091 doi: 10.1046/j.1471-4159.2000.740740.x
69. Kadoshima T, Sakaguchi H, Nakano T, et al. Self-organization 81. Lai JD, Berlind JE, Fricklas G, et al. KCNJ2 inhibition mitigates
of axial polarity, inside-out layer pattern, and species-specific mechanical injury in a human brain organoid model of
progenitor dynamics in human ES cell-derived neocortex. traumatic brain injury. Cell Stem Cell. 2024;31(4):519-536.e8.
Proc Natl Acad Sci U S A. 2013;110(50):20284-20289. doi: 10.1016/j.stem.2024.03.004
doi: 10.1073/pnas.1315710110 82. Beltrán SM, Bobo J, Habib A, et al. Characterization of
70. Paşca AM, Sloan SA, Clarke LE, et al. Functional cortical neural mechanotransduction response in human traumatic
neurons and astrocytes from human pluripotent stem cells brain injury organoid model. Sci Rep. 2023;13(1):13536.
in 3D culture. Nat Methods. 2015;12(7):671-678. doi: 10.1038/s41598-023-40431-y
doi: 10.1038/nmeth.3415 83. Qian X, Nguyen HN, Song MM, et al. Brain-region-specific
71. Ramirez S, Mukherjee A, Sepulveda SE, et al. Protocol for organoids using mini-bioreactors for modeling ZIKV
controlled cortical impact in human cerebral organoids to exposure. Cell. 2016;165(5):1238-1254.
model traumatic brain injury. STAR Protoc. 2021;2(4):100987. doi: 10.1016/j.cell.2016.04.032
doi: 10.1016/j.xpro.2021.100987 84. Wang Z, Wang SN, Xu TY, et al. Cerebral organoids
72. Brain injury awareness month - March 2019. MMWR Morb transplantation improves neurological motor function in rat
Mortal Wkly Rep. 2019;68(10):237. brain injury. CNS Neurosci Ther. 2020;26(7):682-697.
doi: 10.15585/mmwr.mm6810a1 doi: 10.1111/cns.13286
73. Petersilie L, Kafitz KW, Neu LA, et al. Protocol for the 85. Gao X, Wang X, Xiong W, Chen J. In vivo reprogramming
generation of cultured cortical brain organoid slices. STAR reactive glia into iPSCs to produce new neurons in the cortex
Protoc. 2024;5(3):103212. following traumatic brain injury. Sci Rep. 2016;6:22490.
doi: 10.1016/j.xpro.2024.103212 doi: 10.1038/srep22490
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