Page 87 - OR-1-1
P. 87
doi: 10.1126/sciadv.adl1498 157. Jo J, Yang L, Tran HD, et al. Lewy body-like inclusions in
154. Jarazo J, Barmpa K, Modamio J, et al. Parkinson’s disease human midbrain organoids carrying glucocerebrosidase and
phenotypes in patient neuronal cultures and brain organoids α-synuclein mutations. Ann Neurol. 2021;90(3):490-505.
improved by 2-hydroxypropyl-β-cyclodextrin treatment. doi: 10.1002/ana.26166
Mov Disord. 2022;37(1):80-94.
158. Becerra-Calixto A, Mukherjee A, Ramirez S, et al. Lewy
doi: 10.1002/mds.28810
body-like pathology and loss of dopaminergic neurons
155. Zagare A, Barmpa K, Smajic S, et al. Midbrain organoids in midbrain organoids derived from familial Parkinson’s
mimic early embryonic neurodevelopment and recapitulate disease patient. Cells. 2023;12(4):625.
LRRK2-p.Gly2019Ser-associated gene expression. Am J Hum
Genet. 2022;109(2):311-327. doi: 10.3390/cells12040625
doi: 10.1016/j.ajhg.2021.12.009 159. Zheng X, Han D, Liu W, et al. Human iPSC-derived midbrain
156. Mohamed NV, Sirois J, Ramamurthy J, et al. Midbrain organoids functionally integrate into striatum circuits and
organoids with an SNCA gene triplication model key features restore motor function in a mouse model of Parkinson’s
of synucleinopathy. Brain Commun. 2021;3(4):fcab223. disease. Theranostics. 2023;13(8):2673-2692.
doi: 10.1093/braincomms/fcab223 doi: 10.7150/thno.80271
Volume 1 Issue 1 (2025) 21 doi: 10.36922/or.8261

