Page 73 - OR-1-2

A

B

Figure 10. Brain organoids transplantation for stroke brain injury. (A) hMGEO transplantation in stroke. Reproduced from Wang et al. Copyright ©
188
2020, Authors. (B) Cerebral organoids transplantation after stroke. Copyright 2023, Springer Nature.
13
Abbreviations: AAV: Adeno-associated viruses; COs: Cerebral organoids; DAI: Days after induction; DAPI: 4’,6-diamidino-2-phenylindole; DIC: dpi:
Dots per inch; EF1a: Elongation factor 1-alpha 1; EGFP: Enhanced green fluorescent protein; hChR2: Human channel rhodopsin 2; HN: Human
nuclei; HO: Hoechst 33258 dye; LV: Lentivirus; MCAO: Middle cerebral artery occlusio.
regeneration by restoring blood supply, supporting tissue transplanted hESC-derived vascularized BOs into the
repair, and improving survival and functional recovery cortex of immunodeficient mice. The results showed
161
post-transplantation. In a pivotal study, Daviaud et al. that the transplanted V-Organoids integrated with the

Volume 1 Issue 2 (2025) 24 doi: 10.36922/or.8162