Page 163 - OR-1-3

doi: 10.1002/jcsm.13094 tenogenic differentiation protocol for human stem cells. Acta
Biomater. 2022;145:25-42.
40. Jiang Y, Zhou R, Liao F, et al. Unraveling radiation-induced
skeletal muscle damage: Insights from a 3D human skeletal doi: 10.1016/j.actbio.2022.04.028
muscle organoid model. Biochim Biophys Acta Mol Cell Res. 51. Graça AL, Kroner-Weigl N, Reyes Alcaraz V, Müller-
2024;1871(7):119792.
Deubert S, Rudert M, Docheva D. Demonstration of Self-
doi: 10.1016/j.bbamcr.2024.119792 assembled cell sheet culture and manual generation of a
3d tendon/ligament-like organoid by using human dermal
41. Svobodova B, Jelinkova S, Pesl M, et al. Cellular pathology of fibroblasts. J Vis Exp. 2024;(208).
the human heart in Duchenne muscular dystrophy (DMD):
Lessons learned from in vitro modeling. Pflugers Arch. doi: 10.3791/66047
2021;473(7):1099-1115. 52. Zhao F, Cheng J, Sun M, et al. Digestion degree is a key factor
doi: 10.1007/s00424-021-02589-0 to regulate the printability of pure tendon decellularized
extracellular matrix bio-ink in extrusion-based 3D cell
42. Stańczak M, Kacprzak B, Gawda P. Tendon cell biology: printing. Biofabrication. 2020;12(4):045011.
Effect of mechanical loading. Cell Physiol Biochem.
2024;58(6):677-701. doi: 10.1088/1758-5090/aba411
doi: 10.33594/000000743 53. Qiu Y, Lei J, Koob TJ, Temenoff JS. Cyclic tension promotes
fibroblastic differentiation of human MSCs cultured
43. Loiacono C, Palermi S, Massa B, et al. Tendinopathy: on collagen-fibre scaffolds. J Tissue Eng Regen Med.
Pathophysiology, therapeutic options, and role of 2016;10(12):989-999.
nutraceutics. A narrative literature review. Medicina
(Kaunas). 2019;55(8):447. doi: 10.1002/term.1880
doi: 10.3390/medicina55080447 54. Iaquinta MR, Montesi M, Mazzoni E. Advances in bone
biology. Int J Mol Sci. 2024;25(13):6892.
44. De Micheli AJ, Swanson JB, Disser NP, et al. Single-cell
transcriptomic analysis identifies extensive heterogeneity in doi: 10.3390/ijms25136892
the cellular composition of mouse Achilles tendons. Am J 55. Zhao D, Saiding Q, Li Y, Tang Y, Cui W. Bone organoids:
Physiol Cell Physiol. 2020;319(5):C885-C894. Recent advances and future challenges. Adv Healthc Mater.
doi: 10.1152/ajpcell.00372.2020 2024;13(5):e2302088.
45. Bi Y, Ehirchiou D, Kilts TM, et al. Identification of tendon doi: 10.1002/adhm.202302088
stem/progenitor cells and the role of the extracellular matrix 56. Melis S, Trompet D, Chagin AS, Maes C. Skeletal stem and
in their niche. Nat Med. 2007;13(10):1219-1227. progenitor cells in bone physiology, ageing and disease. Nat
doi: 10.1038/nm1630 Rev Endocrinol. 2025;21(3):135-153.
46. Riley G. Tendinopathy--from basic science to treatment. Nat doi: 10.1038/s41574-024-01039-y
Clin Pract Rheumatol. 2008;4(2):82-89. 57. Clarke B. Normal bone anatomy and physiology. Clin J Am
doi: 10.1038/ncprheum0700 Soc Nephrol. 2008;3(Suppl 3):S131-S139.
47. Tam KT, Baar K. Using load to improve tendon/ligament doi: 10.2215/CJN.04151206
tissue engineering and develop novel treatments for 58. Xie C, Liang R, Ye J, et al. High-efficient engineering of
tendinopathy. Matrix Biol. 2025;135:39-54. osteo-callus organoids for rapid bone regeneration within
doi: 10.1016/j.matbio.2024.12.001 one month. Biomaterials. 2022;288:121741.
48. Kroner-Weigl N, Chu J, Rudert M, Alt V, Shukunami C, doi: 10.1016/j.biomaterials.2022.121741
Docheva D. Dexamethasone is not sufficient to facilitate 59. Rodríguez Ruiz A, Van Hoolwerff M, Sprangers S, et al.
tenogenic differentiation of dermal fibroblasts in a 3D Mutation in the CCAL1 locus accounts for bidirectional
organoid model. Biomedicines. 2023;11(3):772. process of human subchondral bone turnover and cartilage
doi: 10.3390/biomedicines11030772 mineralization. Rheumatology (Oxford). 2022;62(1):360-372.
49. Yan Z, Yin H, Brochhausen C, Pfeifer CG, Alt V, Docheva D. doi: 10.1093/rheumatology/keac232
Aged tendon stem/progenitor cells are less competent to 60. O’Connor SK, Katz DB, Oswald SJ, Groneck L, Guilak F.
form 3D tendon organoids due to cell autonomous and Formation of osteochondral organoids from murine
matrix production deficits. Front Bioeng Biotechnol. induced pluripotent stem cells. Tissue Eng Part A.
2020;8:406. 2021;27(15-16):1099-1109.
doi: 10.3389/fbioe.2020.00406 doi: 10.1089/ten.tea.2020.0273
50. Donderwinkel I, Tuan RS, Cameron NR, Frith JE. Tendon 61. Cardier JE, Diaz-Solano D, Wittig O, et al. Osteogenic
tissue engineering: Current progress towards an optimized organoid for bone regeneration: Healing of bone defect in

Volume 1 Issue 3 (2025) 16 doi: 10.36922/OR025320025