Page 164 - OR-1-3

congenital pseudoarthrosis of the tibia. Int J Artif Organs. 73. Zhang Y, Fang Q, Peng Y, et al. Establishment and
2024;47(2):107-114. characterization of an inflammatory cartilaginous organoids
model for organoid transplantation study. J Orthop Translat.
doi: 10.1177/03913988231220844
2025;52:376-386.
62. Fuller J, Lefferts KS, Shah P, Cottrell JA. Methodology and
characterization of a 3d bone organoid model derived from doi: 10.1016/j.jot.2025.05.002
murine cells. Int J Mol Sci. 2024;25(8):4225. 74. Golshan M, Dortaj H, Omidi Z, et al. Cartilage repair:
Unleashing PRP’s potential in organoid models.
doi: 10.3390/ijms25084225
Cytotechnology. 2025;77(3):86.
63. Li C, Zhang Y, Du Y, et al. A review of advanced biomaterials
and cells for the production of bone organoid. Small Sci. doi: 10.1007/s10616-025-00739-1
2023;3(8):2300027. 75. Abe K, Yamashita A, Morioka M, et al. Engraftment
of allogeneic iPS cell-derived cartilage organoid in a
doi: 10.1002/smsc.202300027
primate model of articular cartilage defect. Nat Commun.
64. Park Y, Cheong E, Kwak JG, Carpenter R, Shim JH, Lee J. 2023;14(1):804.
Trabecular bone organoid model for studying the regulation
of localized bone remodeling. Sci Adv. 2021;7(4):eabd6495. doi: 10.1038/s41467-023-36408-0
76. Lin W, Wang M, Xu L, Tortorella M, Li G. Cartilage organoids
doi: 10.1126/sciadv.abd6495
for cartilage development and cartilage-associated disease
65. Frenz-Wiessner S, Fairley SD, Buser M, et al. Generation modeling. Front Cell Dev Biol. 2023;11:1125405.
of complex bone marrow organoids from human induced doi: 10.3389/fcell.2023.1125405
pluripotent stem cells. Nat Methods. 2024;21(5):868-881.
77. Rothbauer M, Byrne RA, Schobesberger S, et al. Establishment
doi: 10.1038/s41592-024-02172-2
of a human three-dimensional chip-based chondro-synovial
66. Iordachescu A, Hughes EAB, Joseph S, Hill EJ, Grover LM, coculture joint model for reciprocal cross talk studies in
Metcalfe AD. Trabecular bone organoids: A micron- arthritis research. Lab Chip. 2021;21(21):4128-4143.
scale ‘humanised’ prototype designed to study the effects doi: 10.1039/d1lc00130b
of microgravity and degeneration. NPJ Microgravity.
2021;7(1):17. 78. Chen Z, Bo Q, Wang C, Xu Y, Fei X, Chen R. Single BMSC-
derived cartilage organoids for gradient heterogeneous
doi: 10.1038/s41526-021-00146-8
osteochondral regeneration by leveraging native vascular
67. Kong Y, Yang Y, Hou Y, Wang Y, Li W, Song Y. Advance in microenvironment. J Nanobiotechnol. 2025;23(1):325.
the application of organoids in bone diseases. Front Cell Dev
Biol. 2024;12:1459891. doi: 10.1186/s12951-025-03403-0
79. Saveh-Shemshaki N, S Nair L, Laurencin CT. Nanofiber-
doi: 10.3389/fcell.2024.1459891
based matrices for rotator cuff regenerative engineering.
68. Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biol. Acta Biomater. 2019;94:64-81.
2018;71-72:51-69.
doi: 10.1016/j.actbio.2019.05.041
doi: 10.1016/j.matbio.2018.05.005
80. Narayanan G, Nair LS, Laurencin CT. Regenerative
69. Bai L, Zhou D, Li G, Liu J, Chen X, Su J. Engineering bone/ engineering of the rotator cuff of the shoulder. ACS Biomater
cartilage organoids: Strategy, progress, and application. Bone Sci Eng. 2018;4(3):751-786.
Res. 2024;12(1):66.
doi: 10.1021/acsbiomaterials.7b00631
doi: 10.1038/s41413-024-00376-y
81. Wang D, Zhang X, Huang S, et al. Engineering multi-tissue
70. Lan X, Boluk Y, Adesida AB. 3D bioprinting of hyaline units for regenerative Medicine: Bone-tendon-muscle units
cartilage using nasal chondrocytes. Ann Biomed Eng. of the rotator cuff. Biomaterials. 2021;272:120789.
2024;52(7):1816-1834.
doi: 10.1016/j.biomaterials.2021.120789
doi: 10.1007/s10439-023-03176-3
82. Mushahary D, Spittler A, Kasper C, Weber V, Charwat V.
71. Shen C, Wang J, Li G, et al. Boosting cartilage repair with silk Isolation, cultivation, and characterization of human
fibroin-DNA hydrogel-based cartilage organoid precursor. mesenchymal stem cells. Cytometry A. 2018;93(1):19-31.
Bioact Mater. 2024;35:429-444.
doi: 10.1002/cyto.a.23242
doi: 10.1016/j.bioactmat.2024.02.016
83. Fakhry M, Hamade E, Badran B, Buchet R, Magne D.
72. Wu Y, Jia Z, Sun K, Zhou G, Tao K. A multi-gradient organoid Molecular mechanisms of mesenchymal stem cell
of articular cartilage with bionic matrix microenvironment. differentiation towards osteoblasts. World J Stem Cells.
Biomaterials. 2025;322:123393. 2013;5(4):136-148.
doi: 10.1016/j.biomaterials.2025.123393 doi: 10.4252/wjsc.v5.i4.136

Volume 1 Issue 3 (2025) 17 doi: 10.36922/OR025320025