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Tumor Discovery The mechanism of cancer-related cognitive decline

that is, executive functions, processing speed, memory, 4. Ren X, Boriero D, Chaiswing L, et al., 2019. Plausible
and attention. At present, although the etiology and biochemical mechanisms of chemotherapy-induced
pathogenesis of CRCI are not well understood, they may cognitive impairment (“chemobrain”), a condition that
be related to the biological effects of cancer, adverse effects significantly impairs the quality of life of many cancer
of cancer treatment, or common potential risk factors for survivors. Biochim Biophys Acta Mol Basis Dis, 1865(6):
1088–1097.
both cancer and cognitive impairment. Further clinical and
basic research is warranted in the future to elucidate the https://doi.org/10.1016/j.bbadis.2019.02.007
actual mechanisms of CRCI to develop detailed diagnosis 5. Ahles TA, Root JC, 2018, Cognitive effects of cancer and
and management strategies for such patients. cancer treatments. Annu Rev Clin Psychol, 14: 425–451.

Acknowledgments https://doi.org/10.1146/annurev-clinpsy-050817-084903
6. Wefel JS, Kesler SR, Noll KR, et al., 2015, Clinical
None.
characteristics, pathophysiology, and management of
Funding noncentral nervous system cancer-related cognitive
impairment in adults. CA Cancer J Clin, 65: 123–138.
This study was supported by the National Natural https://doi.org/10.3322/caac.21258
Science Foundation of China (81870821 and 82071187)
and Beijing Youth Talent Team Support Program 7. Lange M, Joly F, Vardy J, et al., 2019, Cancer-related cognitive
impairment: An update on state of the art, detection, and
(2018000021223TD08).
management strategies in cancer survivors. Ann Oncol,
Conflict of interest 30(12): 1925–1940.
https://doi.org/10.1093/annonc/mdz410
No conflict of interest was reported by all authors.
8. Janelsins MC, Heckler CE, Peppone LJ, et al., 2017, Cognitive
Author contributions complaints in survivors of breast cancer after chemotherapy
compared with age-matched controls: An analysis from a
Conceptualization: Jiwei Jiang, Zhongli Du, Zhimin Bian, nationwide, multicenter, prospective longitudinal study.
Jun Xu J Clin Oncol, 35(5): 506–514.
Data curation: Yanli Wang https://doi.org/10.1200/jco.2016.68.5826
Funding acquisition: Zhimin Bian, Jun Xu 9. Janelsins MC, Kesler SR, Ahles TA, et al., 2014, Prevalence,
mechanisms, and management of cancer-related cognitive
Supervision: Zhimin Bian, Jun Xu
impairment. Int Rev Psychiatry, 26(1): 102–113.
Writing – original draft: Jiwei Jiang, Zhongli Du https://doi.org/10.3109/09540261.2013.864260
Writing – review & editing: Jiwei Jiang, Zhongli Du, Yanli 10. Rummel NG, Chaiswing L, Bondada S, et al., 2021,
Wang, Hanping Shi, Wenyi Li, Yuan Zhang, Mengfan Chemotherapy-induced cognitive impairment: focus on the
Sun, Zhimin Bian, Jun Xu intersection of oxidative stress and TNFα. Cell Mol Life Sci,
78(19–20): 6533–6540.
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