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Tumor Discovery Targeted drug delivery systems for the treatment of tumors

immunoassay and fluorescence microscopy, revealed regimens . Polymers utilized include polyethylene
[36]
the selective accumulation of cetuximab microspheres at glycols, polysaccharides, and polyvinyl alcohol, which not
the targeted tumor site. Conjugated europium antibody only enhance solubility but also extend the circulation
microspheres have the potential for efficient tumor site half-life of the active drug and bypass the opsonization
imaging and accumulation within the tumor in vivo. process. Improved stability, prolonged retention time,
Another micronized delivery system, microemulsions and reduced clearance of polymeric nanoparticles offer
(0.1 μm), serves as adaptable carriers that exhibit enhanced notable applications in oncology. These cargos are actively
[37]
bioavailability of poorly soluble actives, improved taken up by the cell-mediated active transport system .
Moreover, these systems are protected from the unfavorable
absorption, and high permeation due to their small size
distribution and low surface tension . Table 1 compiles environment of the gastrointestinal tract and bypass first-
[26]
a few microscale tumor-targeted delivery approaches and pass metabolism, resulting in increased bioavailability and
their applications. These systems are thermodynamically reduced metabolic clearance. Furthermore, the polymeric
integrity enables a high payload and controlled release
stable and can effectively deliver both hydrophobic and [38]
hydrophilic actives across the skin . of the actives at the target site . Polymeric nanocarriers
[27]
entail the use of polymeric nanoparticles, polymeric
4.2. Nanoscale tumor-targeted drug delivery micelles, dendrimers, and polyplexes for specific drug
systems delivery at the tumor target site, as illustrated in Figure 4,
and they are further elaborated as follows:
4.2.1. Polymeric nanocarriers
Polymeric nanocarriers are considered a promising (a) Polymeric nanoparticles
approach for drug delivery to alleviate various disorders, Nanodimensional particles serve as excellent carriers
including tumors. Their remarkable pharmacokinetic for site-specific drug release and effective antitumor
properties, namely, solubility, stability, significant management by virtue of their biocompatibility and
distribution, and accumulation at tumor cells, have prolonged circulation efficiency. Numerous nanocarriers
garnered attention for developing new chemotherapy (below 1000 nm), including liposomes, polymeric

Table 1. Microscale tumor-targeted delivery systems and their applications

Therapeutic agent and Targeted site Research Objective Application References
formulation
Yttrium-90 microspheres Liver Development of microspheres to provide Local radiotherapy for liver [28]
prolonged patient survival through precisely tumors
nourishing vasculature related to hepatic
tumors
MDHJ (Methyl dihydrojasmonate) Breast Phytochemical MDHJ microemulsion has Targeting solid tumor [29]
containing microemulsion the capability to reduce tumor volume and (transdermally)
necrotic effects in MCF-7 cell lines
Magnetic iron oxide bovine serum Skin Prolonged delivery of sulforaphane through Promising drug carrier for [30]
albumin microspheres iron oxide magnetic microspheres anticancer drug
Mitoxantrone (MXN)-albumin Breast Preparation of MXN microspheres to reduced Localized breast cancer [31]
microspheres toxicity and improved moderate survival in chemotherapy
murine mammary adenocarcinoma
5-fluorouracil microspheres Brain Formulation of biodegradable microspheres Prolonged local delivery of [32]
for sustain release of 5-fluorouracil and 5-fluorouracil in malignant
impressive management of neoplastic cells brain tumor
present in brain tissues
CA125-poly(lactic-co-glycolic Ovary Preparation of antigen CA125-loaded PLGA Immunotherapy of ovarian [33]
acid) (PLGA) microspheres microspheres for induction of T lymphocytes cancer
Pancreatin microspheres Pancreas Development of enteric-coated pancreatin Unresectable pancreatic cancer [34]
microspheres for the direct release in the
pancreatic duct
Paclitaxel microspheres Urinary bladder Development of bioadhesive paclitaxel Intracavitary treatment for [35]
microspheres for the controlled release at the superficial carcinoma of the
urothelium urinary bladder

Volume 2 Issue 3 (2023) 6 https://doi.org/10.36922/td.1356