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Tumor Discovery

PERSPECTIVE ARTICLE
Vasculoendothelial dysfunction and bone health

in obese children: A connection with cancers

Simmi Kharb * and Gurpreet Singh Gill †
†
Department of Biochemistry, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak,
Haryana, India

Abstract
Obesity in children, a growing global epidemic, is not merely characterized by
excessive body fat but also by a cascade of metabolic and functional derangements
with significant musculoskeletal consequences. One of the key underpinnings of
these detrimental effects is vasculoendothelial dysfunction (VED), a multifaceted
pathological process characterized by impaired endothelial cell function. The
endothelium, lining the vasculature, plays a pivotal role in regulating vascular tone,
inflammation, and coagulation, and its dysfunction in obese children leads to a plethora
of downstream complications with profound implications for musculoskeletal and
bone health. Diagnosing VED in obese children remains a challenge. Traditional
cardiovascular risk factors such as hypertension and dyslipidemia are often detected
long after the occurrence of endothelial dysfunction. In the context of bone
sarcoma, the interaction between cancer cells and vascular endothelium in the
† These authors contributed equally bone microenvironment is critical. The bone is a highly vascularized tissue, and the
to this work. vascular endothelium plays a role in regulating bone homeostasis. In the presence
*Corresponding author: of cancer cells, altered bone microenvironment provides a milieu favorable to tumor
Simmi Kharb growth and invasion. The relationship between the vascular endothelium and cancer
(drsimmikharab@uhrs.ac.in) is complex and can vary depending on the type of cancer and its microenvironment.
Citation: Kharb S, Gill GS. Understanding the interactions between vascular endothelium and bone sarcoma is
Vasculoendothelial dysfunction crucial for developing targeted therapies. New molecular and cellular mechanisms
and bone health in obese children: involved in these interactions are awaiting to be uncovered, shedding light on
A connection with cancers. Tumor
Discov. 2024;3(2):2825. potential therapeutic strategies for cancer treatment. On a relevant note, emerging
doi: 10.36922/td.2825 vasculoendothelial markers hold promise for early detection and intervention.
Received: January 25, 2024 Early identification of VED, through the detection of vasculoendothelial markers,
opens doors for timely interventions aimed at preventing its detrimental effects on
Accepted: April 25, 2024
musculoskeletal and bone health in obese children.
Published Online: May 24, 2024
Copyright: © 2024 Author(s). Keywords: Childhood obesity; Vasculoendothelial; Vascular dysfunction; Inflammatory
This is an Open-Access article
distributed under the terms of the markers; Cancer; Bone
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited. 1. Introduction
Publisher’s Note: AccScience Obesity in children, a growing global epidemic, is not merely characterized by excessive
Publishing remains neutral with body fat but also by a cascade of metabolic and functional derangements with significant
regard to jurisdictional claims in
published maps and institutional musculoskeletal and bone health consequences. One of the key underpinnings of
affiliations. these detrimental effects is vasculoendothelial dysfunction (VED), a multifaceted

Volume 3 Issue 2 (2024) 1 doi: 10.36922/td.2825