Page 74 - TD-4-1

Tumor Discovery Drug repurposing for pancreatic cancer via AI

doi: 10.1093/nar/gkq1126 doi: 10.1038/onc.2015.216
35. Kim S, Thiessen PA, Bolton EE, et al. PubChem 47. Wolfer A, Ramaswamy S. MYC and metastasis. Cancer Res.
substance and compound databases. Nucleic Acids Res. 2011;71(6):2034-2037.
2015;44(D1):D1202-D1213.
doi: 10.1158/0008-5472.Can-10-3776
doi: 10.1093/nar/gkv951
48. Liu YH, Gan YX, Chen JZ, Jiang YX, Huang F, Tang D.
36. Gaulton A, Hersey A, Nowotka M, et al. The ChEMBL Targeting MYC to combat pancreatic cancer. J Explor Rese
database in 2017. Nucleic Acids Res. 2016;45(D1):D945-D954. Pharmacol. 2022;7(3):164-178.
doi: 10.1093/nar/gkw1074 doi: 10.14218/jerp.2021.00015
37. Kuhn M, von Mering C, Campillos M, Jensen LJ, Bork P. 49. Wirth M, Mahboobi S, Krämer OH, Schneider G. Concepts
STITCH: Interaction networks of chemicals and proteins. to target MYC in pancreatic cancer. Mol Cancer Ther.
Nucleic Acids Res. 2007;36(suppl_1):D684-D688. 2016;15(8):1792-1798.
doi: 10.1093/nar/gkm795 doi: 10.1158/1535-7163.Mct-16-0050
38. Ringnér M. What is principal component analysis? Nat 50. Ala M. Target c-Myc to treat pancreatic cancer. Cancer Biol
Biotechnol. 2008;26(3):303-304. Ther. 2022;23(1):34-50.
doi: 10.1038/nbt0308-303 doi: 10.1080/15384047.2021.2017223
39. Huber M, Brehm CU, Gress TM, et al. The immune 51. Farrell AS, Joly MM, Allen-Petersen BL, et al. MYC regulates
microenvironment in pancreatic cancer. Int J Mol Sci. ductal-neuroendocrine lineage plasticity in pancreatic
2020;21(19):7307. ductal adenocarcinoma associated with poor outcome and
chemoresistance. Nature Commun. 2017;8(1):1728.
doi: 10.3390/ijms21197307
doi: 10.1038/s41467-017-01967-6
40. Truong LH, Pauklin S. Pancreatic cancer microenvironment
and cellular composition: Current understandings and 52. Fujiwara-Tani R, Sasaki T, Bhawal UK, et al. Nuclear MAST4
therapeutic approaches. Cancers (Basel). 2021;13(19):5028. suppresses FOXO3 through interaction with AKT3 and
induces chemoresistance in pancreatic ductal carcinoma.
doi: 10.3390/cancers13195028
Int J Mol Sci. 2024;25(7):4056.
41. Cortesi M, Zanoni M, Pirini F, et al. Pancreatic cancer and
cellular senescence: Tumor microenvironment under the doi: 10.3390/ijms25074056
spotlight. Int J Mol Sci. 2022;23(1):254. 53. Luo X, Yang Z, Liu X, et al. The clinicopathological
significance of forkhead box P1 and forkhead box O3a
doi: 10.3390/ijms23010254
in pancreatic ductal adenocarcinomas. Tumor Biol.
42. Arneth B. Tumor microenvironment. Medicina (Kaunas). 2017;39(5):1010428317699129.
2020;56(1):15.
doi: 10.1177/1010428317699129
doi: 10.3390/medicina56010015
54. Feng S, Jiang ZJ, Yu D, Li J, Liu G, Sun JJ. FOXO3a
43. Stopa KB, Kusiak AA, Szopa MD, Ferdek PE, Jakubowska MA. expression and its diagnostic value in pancreatic
Pancreatic cancer and its microenvironment-recent advances ductal adenocarcinoma. Int J Clin Exp Pathol.
and current controversies. Int J Mol Sci. 2020;21(9):3218. 2018;11(11):5422-5429.
doi: 10.3390/ijms21093218 55. Yu S, Yu Y, Sun Y, et al. Activation of FOXO3a suggests good
44. Javadrashid D, Baghbanzadeh A, Derakhshani A, et al. prognosis of patients with radically resected gastric cancer.
Pancreatic cancer signaling pathways, genetic alterations, Int J Clin Exp Pathol. 2015;8(3):2963-2970.
and tumor microenvironment: The barriers affecting the 56. McCubrey JA, Yang LV, Abrams SL, et al. Effects of TP53
method of treatment. Biomedicines. 2021;9(4):373. mutations and mirs on immune responses in the tumor
microenvironment important in pancreatic cancer
doi: 10.3390/biomedicines9040373
progression. Cells. 2022;11(14):2155.
45. Ma Y, Shen N, Wicha MS, Luo M. The roles of the let-7
family of MicroRNAs in the regulation of cancer stemness. doi: 10.3390/cells11142155
Cells. 2021;10(9):2415. 57. Stefanoudakis D, Frountzas M, Schizas D, Michalopoulos NV,
Drakaki A, Toutouzas KG. Significance of TP53, CDKN2A,
doi: 10.3390/cells10092415
SMAD4 and KRAS in pancreatic cancer. Curr Issues Mol
46. Hessmann E, Schneider G, Ellenrieder V, Siveke JT. MYC Biol. 2024;46(4):2827-2844.
in pancreatic cancer: Novel mechanistic insights and
their translation into therapeutic strategies. Oncogene. doi: 10.3390/cimb46040177
2016;35(13):1609-1618. 58. Subramanian A, Narayan R, Corsello SM, et al. A next

Volume 4 Issue 1 (2025) 66 doi: 10.36922/td.4709