Page 49 - TD-4-2

Tumor Discovery Understanding glioblastoma invasion and therapy

with malignant glioma. Cancer Res. 2006;66(6):3294-3302. doi: 10.1016/j.trecan.2020.01.009
doi: 10.1158/0008-5472.Can-05-3773 180. Lan X, Jörg DJ, Cavalli FMG, et al. Fate mapping of human
glioblastoma reveals an invariant stem cell hierarchy. Nature.
169. Patel AP, Tirosh I, Trombetta JJ, et al. Single-cell RNA-seq 2017;549(7671):227-232.
highlights intratumoral heterogeneity in primary
glioblastoma. Science. 2014;344(6190):1396-1401. doi: 10.1038/nature23666
doi: 10.1126/science.1254257 181. Piccirillo SGM, Colman S, Potter NE, et al. Genetic and
functional diversity of propagating cells in glioblastoma.
170. Wang Q, Hu B, Hu X, et al. Tumor evolution of glioma- Stem Cell Reports. 2015;4(1):7-15.
intrinsic gene expression subtypes associates with
immunological changes in the microenvironment. Cancer doi: 10.1016/j.stemcr.2014.11.003
Cell. 2017;32(1):42-56.e6. 182. Lomonaco SL, Finniss S, Xiang C, et al. The induction
doi: 10.1016/j.ccell.2017.06.003 of autophagy by gamma-radiation contributes to the
radioresistance of glioma stem cells. Int J Cancer.
171. Wang J, Cazzato E, Ladewig E, et al. Clonal evolution of 2009;125(3):717-722.
glioblastoma under therapy. Nat Genet. 2016;48(7):768-776.
doi: 10.1002/ijc.24402
doi: 10.1038/ng.3590
183. Bleau AM, Hambardzumyan D, Ozawa T, et al. PTEN/PI3K/
172. Touat M, Li YY, Boynton AN, et al. Mechanisms and Akt pathway regulates the side population phenotype and
therapeutic implications of hypermutation in gliomas. ABCG2 activity in glioma tumor stem-like cells. Cell Stem
Nature. 2020;580(7804):517-523. Cell. 2009;4(3):226-235.
doi: 10.1038/s41586-020-2209-9 doi: 10.1016/j.stem.2009.01.007
173. Kim H, Zheng S, Amini SS, et al. Whole-genome and 184. Lee JH, Lee JE, Kahng JY, et al. Human glioblastoma
multisector exome sequencing of primary and post- arises from subventricular zone cells with low-level driver
treatment glioblastoma reveals patterns of tumor evolution. mutations. Nature. 2018;560(7717):243-247.
Genome Res. 2015;25(3):316-327.
doi: 10.1038/s41586-018-0389-3
doi: 10.1101/gr.180612.114
185. Barami K, Sloan AE, Rojiani A, Schell MJ, Staller A,
174. Segerman A, Niklasson M, Haglund C, et al. Clonal variation Brem S. Relationship of gliomas to the ventricular walls.
in drug and radiation response among glioma-initiating J Clin Neurosci. 2009;16(2):195-201.
cells is linked to proneural-mesenchymal transition. Cell
Rep. 2016;17(11):2994-3009. doi: 10.1016/j.jocn.2008.03.006
doi: 10.1016/j.celrep.2016.11.056 186. Stiles CD, Rowitch DH. Glioma stem cells: A midterm exam.
Neuron. 2008;58(6):832-846.
175. Chen J, Li Y, Yu TS, et al. A restricted cell population
propagates glioblastoma growth after chemotherapy. Nature. doi: 10.1016/j.neuron.2008.05.031
2012;488(7412):522-526. 187. de Groot J, Sontheimer H. Glutamate and the biology of
doi: 10.1038/nature11287 gliomas. Glia. 2011;59(8):1181-1189.
176. Singh SK, Clarke ID, Terasaki M, et al. Identification of doi: 10.1002/glia.21113
a cancer stem cell in human brain tumors. Cancer Res. 188. Smits A, Jin Z, Elsir T, et al. GABA-A channel subunit
2003;63(18):5821-5828. expression in human glioma correlates with tumor histology
177. Singh SK, Hawkins C, Clarke ID, et al. Identification of human and clinical outcome. PLoS One. 2012;7(5):e37041.
brain tumour initiating cells. Nature. 2004;432(7015):396-401. doi: 10.1371/journal.pone.0037041
doi: 10.1038/nature03128 189. Aldape K, Brindle KM, Chesler L, et al. Challenges to curing
primary brain tumours. Nat Rev Clin Oncol. 2019;16(8):
178. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells
promote radioresistance by preferential activation of the 509-520.
DNA damage response. Nature. 2006;444(7120):756-760. doi: 10.1038/s41571-019-0177-5
doi: 10.1038/nature05236 190. Monje M, Borniger JC, D’Silva NJ, et al. Roadmap for the
emerging field of cancer neuroscience. Cell. 2020;181(2):
179. Prager BC, Bhargava S, Mahadev V, Hubert CG, Rich JN.
Glioblastoma stem cells: Driving resilience through chaos. 219-222.
Trends Cancer. 2020;6(3):223-235. doi: 10.1016/j.cell.2020.03.034

Volume 4 Issue 2 (2025) 41 doi: 10.36922/td.8578